The Potential Role of Inflammation Associated with Interaction between Osteopontin and CD44 in a Case of Pulmonary Tumor Thrombotic Microangiopathy Caused by Breast Cancer

被引：17

作者：

Higashi, Akifumi ^{[1
]}

Dohi, Yoshihiro ^{[1
]}

Uraoka, Naohiro ^{[2
]}

Sentani, Kazuhiro ^{[2
]}

Uga, Sayuri ^{[1
]}

Kinoshita, Hiroki ^{[1
]}

Sada, Yoshiharu ^{[1
]}

Kitagawa, Toshiro ^{[1
]}

Hidaka, Takayuki ^{[1
]}

Kurisu, Satoshi ^{[1
]}

Yamamoto, Hideya ^{[1
]}

Yasui, Wataru ^{[2
]}

Kihara, Yasuki ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Cardiovasc Med, Hiroshima 730, Japan

[2] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Mol Pathol, Hiroshima 730, Japan

来源：

INTERNAL MEDICINE | 2015年 / 54卷 / 22期

基金：

日本学术振兴会;

关键词：

pulmonary tumor thrombotic microangiopathy; pulmonary hypertension; osteopontin; CD44; SQUAMOUS-CELL CARCINOMA; ARTERIAL-HYPERTENSION; EXPRESSION; SURVIVAL;

D O I：

10.2169/internalmedicine.54.4749

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare and fatal cancer-related complication. We herein present a case of PTTM that diagnosed antemortem by lung scintigraphy and pulmonary microvascular cytology. The patient was treated with steroid pulse therapy. Although her symptoms temporarily improved, she died of respiratory failure. An autopsy showed PTTM, and an immunohistochemical analysis revealed the expression of osteopontin and CD44 in macrophages that had migrated into the PTTM lesions. These findings suggest that inflammation associated with the interaction between osteopontin and CD44 may play an important role in PTTM.

引用

页码：2877 / 2880

页数：4

共 32 条

[31] Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (Macrophage-Colony stimulating factor) production and breast tumor progression
Bourguignon, LYW
Singleton, PA
Zhu, HB
Diedrich, F
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (32) : 29420 - 29434
[32] Interaction of low molecular weight hyaluronan with CD44 and toll-like receptors promotes the actin filament-associated protein 110-actin binding and MyD88-NFκB signaling leading to proinflammatory cytokine/chemokine production and breast tumor invasion
Bourguignon, Lilly Y. W.
Wong, Gabriel
Earle, Christine A.
Xia, Weiliang
CYTOSKELETON, 2011, 68 (12) : 671 - 693

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