PLCξ (zeta):: A sperm protein that triggers Ca2+ oscillations and egg activation in mammals

被引：175
作者：
Swann, K.
Saunders, C. M.
Rogers, N. T.
Lai, F. A.
机构：
[1] Cardiff Univ, Sch Med, Dept Obstet & Gynaecol, Cardiff CF14 4XN, Wales
[2] Cardiff Univ, Sch Med, Wales Heart Res Inst, Cell Signalling Lab, Cardiff CF14 4XN, Wales
[3] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2006年 / 17卷 / 02期
基金：
英国惠康基金;
关键词：
fertilization; calcium; phospholipase; egg; sperm;
D O I：
10.1016/j.semcdb.2006.03.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
At fertilization in mammals, the sperm activates development by causing a prolonged series of intracellular Ca2+ oscillations that are generated by increased production of inositol trisphosphate (InsP(3)). It appears that the sperm initiates InsP(3) generation via the introduction of a sperm factor into the egg after gamete membrane fusion. We recently identified a sperm-specific form of phospholipase C (PLC), referred to as PLC zeta(zeta). We review the evidence that PLC zeta represents the sperm factor that activates development of the egg and discuss the characteristics of PLC zeta that distinguish it from the somatic forms of PLC. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：264 / 273
页数：10
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