NIR-Triggered Hyperthermal Effect of Polythiophene Nanoparticles Synthesized by Surfactant-Free Oxidative Polymerization Method on Colorectal Carcinoma Cells

被引：17
作者：
Bhattarai, Deval Prasad [1 ]
Kim, Beom Su [2 ]
机构：
[1] Tribhuvan Univ, Dept Chem, Amrit Campus, Kathmandu 44613, Nepal
[2] Chonbuk Natl Univ, Carbon Nano Convergence Technol Ctr Next Generat, 567 Baekje Daero, Jeonju Si 54896, South Korea
来源：
CELLS | 2020年 / 9卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
polythiophene nanoparticles; chemical polymerization; photothermal; CT-26; cells; cancer treatment; apoptotic cell death; ENDOPLASMIC-RETICULUM; FACILE SYNTHESIS; THIN-FILMS; METASTASES; THIOPHENE; APOPTOSIS;
D O I：
10.3390/cells9092122
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this work, polythiophene nanoparticles (PTh-NPs) were synthesized by a surfactant-free oxidative chemical polymerization method at 60 degrees C, using ammonium persulphate as an oxidant. Various physicochemical properties were studied in terms of field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Fourier transform infra-red (FT-IR) spectroscopy, and differential scanning calorimetry (DSC)/thermogravimetric analysis (TGA). Photothermal performance of the as-synthesized PTh-NPs was studied by irradiating near infra-red of 808 nm under different concentration of the substrate and power supply. The photothermal stability of PTh-NPs was also studied. Photothermal effects of the as-synthesized PTh-NPs on colorectal cancer cells (CT-26) were studied at 100 mu g/mL concentration and 808 nm NIR irradiation of 2.0 W/cm(2) power. Our in vitro results showed remarkable NIR laser-triggered photothermal apoptotic cell death by PTh-NPs. Based on the experimental findings, it is revealed that PTh-NPs can act as a heat mediator and can be an alternative material for photothermal therapy in cancer treatment.
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页码：1 / 11
页数：11
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