Novel Mechanisms of Regulation of miRNAs in CLL

被引：32

作者：

Balatti, Veronica ^{[1
]}

Acunzo, Mario ^{[1
]}

Pekarky, Yuri ^{[1
]}

Croce, Carlo M. ^{[1
]}

机构：

[1] Ohio State Univ, Wexner Med Ctr, Comprehens Canc Ctr, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

TRENDS IN CANCER | 2016年 / 2卷 / 03期

关键词：

CLL; miR-15/16; miRNA;

D O I：

10.1016/j.trecan.2016.02.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

B cell chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. Despite this, the molecular alterations leading to CLL onset and progression are still under investigation, specifically, the interplay and exact role of oncogenes and tumor suppressors. miRNAs are small noncoding RNAs that regulate gene expression and are expressed in a tissue-specific manner. Deregulation of miRNAs can alter expression levels of genes involved in the development and/or progression of tumors. In CLL, miRNAs can function as oncogenes or tumor suppressors. Here, we review the most recent findings on the role of miRNAs in CLL and discuss how this knowledge can be used to identify new biomarkers and targets to treat this leukemia.

引用

页码：134 / 143

页数：10

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