Novel Mechanisms of Regulation of miRNAs in CLL

被引：32

作者：

Balatti, Veronica ^{[1
]}

Acunzo, Mario ^{[1
]}

Pekarky, Yuri ^{[1
]}

Croce, Carlo M. ^{[1
]}

机构：

[1] Ohio State Univ, Wexner Med Ctr, Comprehens Canc Ctr, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

TRENDS IN CANCER | 2016年 / 2卷 / 03期

关键词：

CLL; miR-15/16; miRNA;

D O I：

10.1016/j.trecan.2016.02.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

B cell chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. Despite this, the molecular alterations leading to CLL onset and progression are still under investigation, specifically, the interplay and exact role of oncogenes and tumor suppressors. miRNAs are small noncoding RNAs that regulate gene expression and are expressed in a tissue-specific manner. Deregulation of miRNAs can alter expression levels of genes involved in the development and/or progression of tumors. In CLL, miRNAs can function as oncogenes or tumor suppressors. Here, we review the most recent findings on the role of miRNAs in CLL and discuss how this knowledge can be used to identify new biomarkers and targets to treat this leukemia.

引用

页码：134 / 143

页数：10

共 72 条

[1] Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia [J].

Allegra, D. ;

Bilan, V. ;

Garding, A. ;

Doehner, H. ;

Stilgenbauer, S. ;

Kuchenbauer, F. ;

Mertens, D. .

LEUKEMIA, 2014, 28 (01) :98-107

[2] microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia [J].

Asslaber, Daniela ;

Pinon, Josefina D. ;

Seyfried, Irina ;

Desch, Petra ;

Stoecher, Markus ;

Tinhofer, Inge ;

Egle, Alexander ;

Merkel, Olaf ;

Greil, Richard .

BLOOD, 2010, 115 (21) :4191-4197

[3] Epigenetic silencing of miR-708 enhances NF-B signaling in chronic lymphocytic leukemia [J].

Baer, Constance ;

Oakes, Christopher C. ;

Ruppert, Amy S. ;

Claus, Rainer ;

Kim-Wanner, Soo-Zin ;

Mertens, Daniel ;

Zenz, Thorsten ;

Stilgenbauer, Stephan ;

Byrd, John C. ;

Plass, Christoph .

INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (06) :1352-1361

[4] TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocytic leukemia [J].

Balatti, Veronica ;

Rizzotto, Lara ;

Miller, Cecelia ;

Palamarchuk, Alexey ;

Fadda, Paolo ;

Pandolfo, Rosantony ;

Rassenti, Laura Z. ;

Hertlein, Erin ;

Ruppert, Amy S. ;

Lozanski, Arletta ;

Lozanski, Gerard ;

Kipps, Thomas J. ;

Byrd, John C. ;

Croce, Carlo M. ;

Pekarsky, Yuri .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (07) :2169-2174

[5] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[6] The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes [J].

Bomben, R. ;

Gobessi, S. ;

Dal Bo, M. ;

Volinia, S. ;

Marconi, D. ;

Tissino, E. ;

Benedetti, D. ;

Zucchetto, A. ;

Rossi, D. ;

Gaidano, G. ;

Del Poeta, G. ;

Laurenti, L. ;

Efremov, D. G. ;

Gattei, V. .

LEUKEMIA, 2012, 26 (07) :1584-1593

[7] p53-mediated activation of miRNA34 candidate tumor-suppressor genes [J].

Bommer, Guido T. ;

Gerin, Isabelle ;

Feng, Ying ;

Kaczorowski, Andrew J. ;

Kuick, Rork ;

Love, Robert E. ;

Zhai, Yali ;

Giordano, Thomas J. ;

Qin, Zhaohui S. ;

Moore, Bethany B. ;

MacDougald, Ormond A. ;

Cho, Kathleen R. ;

Fearon, Eric R. .

CURRENT BIOLOGY, 2007, 17 (15) :1298-1307

[8] miR-181b as a therapeutic agent for chronic lymphocytic leukemia in the Eμ-TCL1 mouse model [J].

Bresin, Antonella ;

Callegari, Elisa ;

D'Abundo, Lucilla ;

Cattani, Caterina ;

Bassi, Cristian ;

Zagatti, Barbara ;

Narducci, M. Grazia ;

Caprini, Elisabetta ;

Pekarsky, Yuri ;

Croce, Carlo M. ;

Sabbioni, Silvia ;

Russo, Giandomenico ;

Negrini, Massimo .

ONCOTARGET, 2015, 6 (23) :19807-19818

[9]

Bullrich F., 2001, Basic and Clinical Oncology, V2, P9

[10] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

← 1 2 3 4 5 6 7 8 →