The role of noncoding regions of classical swine fever virus C-strain in its adaptation to the rabbit

被引：11

作者：

Li, Chao ^{[1
]}

Li, Yongfeng ^{[1
]}

Shen, Liang ^{[1
]}

Huang, Junhua ^{[1
]}

Sun, Yuan ^{[1
]}

Luo, Yuzi ^{[1
]}

Zhao, Bibo ^{[1
]}

Wang, Chunhua ^{[1
]}

Yuan, Jin ^{[1
]}

Qiu, Hua-Ji ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150001, Heilongjiang, Peoples R China

来源：

VIRUS RESEARCH | 2014年 / 183卷

关键词：

Classical swine fever virus; C-strain; Noncoding regions; Adaptation to the rabbit; Fever induction; Replication in the spleen; TIME RT-PCR; E2; GLYCOPROTEIN; INFECTIOUS RNA; 3'-UNTRANSLATED REGION; DIFFERENTIAL DETECTION; 12-NT INSERTION; WILD-TYPE; VIRULENCE; TERMINUS; VACCINE;

D O I：

10.1016/j.virusres.2014.02.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Classical swine fever (CSF) is a devastating disease of swine caused by classical swine fever virus (CSFV). C-strain, a modified live vaccine against CSF, was developed through hundreds of passages of a highly virulent CSFV in the rabbit in China in the mid-1950s. To identify the role of noncoding regions (NCRs) of C-strain in its adaptation to the rabbit, we generated and evaluated a series of chimeric viruses derived from C-strain and the highly virulent Shimen strain. The results demonstrated that the NCRs of the C-strain were essential for its fever induction in rabbits and the coding region but not NCRs was necessary for its replication in the spleen of rabbits. (c) 2014 Elsevier B.V. All rights reserved.

引用

页码：117 / 122

页数：6

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