Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors

被引：44
作者：
Chakravarty, Swapnajit [1 ]
Hosseini, Amir [1 ]
Xu, Xiaochuan [1 ]
Zhu, Liang [2 ]
Zou, Yi [2 ]
Chen, Ray T. [1 ,2 ]
机构：
[1] Omega Opt Inc, Austin, TX 78757 USA
[2] Univ Texas Austin, Dept Elect & Comp Engn, Austin, TX 78758 USA
来源：
APPLIED PHYSICS LETTERS | 2014年 / 104卷 / 19期
关键词：
LABEL-FREE DETECTION; SILICON; BIOSENSOR;
D O I：
10.1063/1.4875903
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
We analyze the contributions of quality factor, fill fraction, and group index of chip-integrated resonance microcavity devices, to the detection limit for bulk chemical sensing and the minimum detectable biomolecule concentration in biosensing. We analyze the contributions from analyte absorbance, as well as from temperature and spectral noise. Slow light in two-dimensional photonic crystals provide opportunities for significant reduction of the detection limit below 1 x 10(-7) RIU (refractive index unit) which can enable highly sensitive sensors in diverse application areas. We demonstrate experimentally detected concentration of 1 fM (67 fg/ml) for the binding between biotin and avidin, the lowest reported till date. (C) 2014 AIP Publishing LLC.
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页数：5
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