Indirect Determination of Methimazole in Pharmaceutical Sample by Discoloration Spectrophotometry Using Fe(III)-Tiron System

被引：1

作者：

Tu, Changqing ^{[1
]}

Wen, Xinrong ^{[1
]}

机构：

[1] Jiaying Univ, Coll Chem & Environm, Meizhou 514015, Guangdong, Peoples R China

来源：

ADVANCES IN CHEMICAL ENGINEERING III, PTS 1-4 | 2013年 / 781-784卷

关键词：

Methimazole; Fe(III); Tiron; Discoloration spectrophotometry; VOLTAMMETRIC DETERMINATION; ELECTRODE; SERUM;

D O I：

10.4028/www.scientific.net/AMR.781-784.115

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A novel method for the indirect determination of methimazole by discoloration spectrophotometry using Fe(III)-tiron system has been established. The various effect factors on the determination of methimazole by discoloration spectrophotometry using tiron-Fe(III) system were investigated in detail. The results showed that by controlling pH=2.8,Fe(III) could be reduced to Fe( II) by hydrosulfuryl(-SH) in methimazole molecule,and then using tiron as chromogenic reagent of Fe(III),and the content of methimazole was determinated indirectly through determinating the surplus content of Fe(III) in the system. The maximum absorption wavelength of chromogenic system was 663 nm, good linear relationship was obtained between AA and the concentration of methimazole in the range of 3.2 similar to 12.8 mu g.mL(-1),the equation of the linear regression was Delta A=-0.1849+57.277p (mg.mL(-1)),with a linear correlation coefficient was 0.9998. This proposed method had been successfully applied to determinate of methimazole in real pharmaceutical.

引用

页码：115 / 119

页数：5

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