Isolated antibodies against the core antigen of hepatitis B virus in HIV-infected patients

被引：30

作者：

Neau, D

Winnock, M

Galpérine, T

Jouvencel, AC

Castéra, L

Legrand, E

Tranchant, E

Balestre, E

Lacoste, D

Ragnaud, JM

Dupon, M

Lafon, ME

Dabis, F

机构：

[1] Hop Pellegrin, Federat Infect & Trop Dis, F-33076 Bordeaux, France

[2] Victor Segalen Univ, INSERM, U593, ISPED, Bordeaux, France

[3] Hop Pellegrin, Dept Virol, F-33076 Bordeaux, France

[4] St Andre Hosp, Hepato Gastroenterol Dept, Bordeaux, France

[5] Haut Leveque Hosp, Pessac, France

[6] St Andre Hosp, Federat Internal Med & Infect Dis, Bordeaux, France

来源：

HIV MEDICINE | 2004年 / 5卷 / 03期

关键词：

HCV coinfection; hepatitis B virus; isolated anti-HBc antibodies; occult HBV infection;

D O I：

10.1111/j.1468-1293.2004.00206.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The aim of this study was to describe the frequency and significance of isolated antibodies against the hepatitis B virus (HBV) core antigen (HBc) in 2185 HIV-infected patients of the Aquitaine Cohort. Antibodies against HBc were found in 372 subjects (17%). Patients with isolated anti-HBc antibodies were more frequently coinfected with hepatitis C virus (HCV) (58.2%) than those who were anti-HB surface (HBs) antibody positive (22.9%, P<0.001) and those who were dually reactive anti-HBs/anti-HBc antibody positive (27.3%, P<0.001). These results suggest interactions between HBV and HCV. As observed in patients not infected with HIV, the 'anti-HBc-alone' serological profile could reflect essentially late immunity with undetectable anti-HBs antibodies. However, an occult HBV infection cannot be ruled out.

引用

页码：171 / 173

页数：3

共 14 条

[1] Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen:: Clinically significant or purely "occult"? [J].