Lowly Expressed Human MicroRNA Genes Evolve Rapidly

被引：72
作者：
Liang, Han [1 ]
Li, Wen-Hsiung [1 ,2 ]
机构：
[1] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA
[2] Acad Sinica, Biodivers Res Ctr, Taipei 115, Taiwan
来源：
MOLECULAR BIOLOGY AND EVOLUTION | 2009年 / 26卷 / 06期
基金：
美国国家卫生研究院;
关键词：
microRNA expression; sequence divergence; spatial clustering; selective pressure; EVOLUTION; DROSOPHILA; SEQUENCES; TARGETS; SITES; DEATH;
D O I：
10.1093/molbev/msp053
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To study the evolution of human microRNAs (miRNAs), we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that similar to 30% of currently annotated human miRNA genes are almost free of selective pressure.
引用
收藏
页码：1195 / 1198
页数：4
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