Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase

被引：25

作者：

Bie, Jianbo

Liu, Shuainan

Zhou, Jie

Xu, Bailing ^{[1
]}

Shen, Zhufang

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Act Substance Discovery & Druggab, Beijing 100050, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2014年 / 22卷 / 06期

基金：

北京市自然科学基金;

关键词：

Fructose-1; 6-Bisphosphatase inhibitor; Allosteric inhibitor; Indole; Diabetes; HUMAN LIVER FRUCTOSE-1,6-BISPHOSPHATASE; FRUCTOSE 1,6-BISPHOSPHATASE INHIBITORS; AMP MIMICS; GLUCOSE-PRODUCTION; RAT-LIVER; DISCOVERY; BINDING; SERIES; HYPERGLYCEMIA; PRODRUGS;

D O I：

10.1016/j.bmc.2014.01.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel indole derivatives was synthesized as inhibitors of fructose-1,6-bisphosphatase (FBPase). Extensive structure-activity relationships were conducted and led to a potent FBPase inhibitor 3.9 with an IC50 of 0.99 mu M. The binding mode of this series of indoles was predicted using CDOCKER algorithm. The results of this research will shed light on the further design and optimization of novel small molecules as FBPase inhibitors. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1850 / 1862

页数：13

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