Vascular endothelial growth factor association with angiopoietin 1 promotes improvement in ventricular function after ischemic cardiomyopathy induced in mini pigs1

被引：1

作者：

de Abreu Oliveira, Andre Lacerda ^{[1
]}

Scheffer, Jussara Peters ^{[2
]}

Markoski, Melissa ^{[3
]}

Koche, Andreia ^{[3
]}

Balbinot, Alexsandra ^{[3
]}

Antunes, Fernanda ^{[2
]}

Kalil, Renato ^{[3
]}

机构：

[1] Univ Estadual Norte Fluminense Darcy Ribeiro UENF, Ctr Agr Sci & Technol, Anim Experimentat Unit, Lab Anim Hlth, Campos Dos Goytacazes, RJ, Brazil

[2] UENF Darcy Ribeiro, Ctr Agr Sci & Technol, Anim Experimentat Unit, Lab Anim Hlth, Campos Dos Goytacazes, RJ, Brazil

[3] Univ Fdn Cardiol, Inst Cardiol Rio Grande do Sul, Porto Alegre, RS, Brazil

来源：

ACTA CIRURGICA BRASILEIRA | 2018年 / 33卷 / 04期

关键词：

Genetic Therapy; Myocardial Infarction; Tissue; Swine; Miniature; STEM-CELL THERAPY; HEART-DISEASE; STROMAL CELLS; REGENERATION; PERFUSION;

D O I：

10.1590/s0102-865020180040000010

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Purpose: To Investigate the safety and clinical, hemodynamic and tissue Improvement ability In mini pigs undergoing cell and gene therapy for the treatment of acute myocardial Infarction. Methods: Thirty-two mini pigs Br1 lineage, 12 months old, undergoing induction of acute myocardial infarction by occlusion of the diagonal branch of the paraconal coronary. They were divided into 4 groups; one control group and 3 treatment groups (cell therapy and gene cell therapy). Echocardiography reviews were performed on three occasions and hlstopathologlcal analysis was performed after 4 weeks. Analysis of variance (ANOVA), Tukey and Wilcoxon tests, were performed. Results: Association of vascular endothelial growth factor (VEGF) with anglopoletinl (Angl) presented satisfactory results In the Improvement of ventricular function following ischemic cardiomyopathy In mini pigs when compared to the results of the other treated groups. Conclusion: The therapy with VEGF and the combination of VEGF with Ang1, promoted recovered function of the myocardium, characterized by reduced akinetic area and Induction of neovascularization.

引用

页码：386 / 395

页数：10

共 25 条

[1]

Angeli Franca Stedile, 2007, Rev. Bras. Cardiol. Invasiva, V15, P145, DOI 10.1590/S2179-83972007000200010

[2] Coordinated activation of VEGFR-1 and VEGFR-2 is a potent arteriogenic stimulus leading to enhancement of regional perfusion [J].