One-pot synthesis of multisubstituted quaterphenyls and cyclopropanes

被引：9

作者：

Chang, Meng-Yang ^{[1
]}

Chan, Chieh-Kai ^{[1
]}

Lin, Shin-Ying ^{[1
]}

Wu, Ming-Hao ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807, Taiwan

来源：

TETRAHEDRON | 2013年 / 69卷 / 47期

关键词：

Quaterphenyls; Cyclopropanes; Chalcones; Cinnamyl sulfones; Electrocyclization; Intramolecular ring-closure; JULIA-KOCIENSKI OLEFINATION; CONTAINING NATURAL-PRODUCTS; SUZUKI-MIYAURA REACTIONS; CROSS-COUPLING REACTIONS; P-TERPHENYL DERIVATIVES; ORGANIC-SYNTHESIS; REGIOSELECTIVE CYCLOTRIMERIZATION; ALKYNE CYCLOTRIMERIZATION; EFFICIENT SYNTHESIS; TERMINAL ALKYNES;

D O I：

10.1016/j.tet.2013.09.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-step synthetic route toward multifunctionalized quaterphenyls 3 or cyclopropanes 4 is developed from substituted chalcones 1 and sulfones 2 in good yields via a regioselective [3C+3C] or [1C+2C] annulation. The reaction features mild conditions, multisubstitution, and functional groups tolerance and is transition metal catalyst-free. The protocol provides a novel alternative to the conventional methodologies for the synthesis of quaterphenyls or cyclopropanes. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：10036 / 10044

页数：9

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