Optical coherent tomographic angiographic pattern of the deep choroidal layer and choriocapillaris after photodynamic therapy for central serous chorioretinopathy

被引:10
作者
Chan, Szy Yann [1 ]
Pan, Chung Ting [2 ]
Wang, Qian [3 ]
Shi, Xue Hui [3 ]
Jonas, Jost B. [4 ]
Wei, Wen Bin [4 ]
机构
[1] Peking Univ, Hosp 3, Beijing Key Lab Restorat Damaged Ocular Nerve, Dept Ophthalmol, Beijing, Peoples R China
[2] Peking Univ, Int Hosp, Dept Ophthalmol, Beijing, Peoples R China
[3] Capital Med Univ, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Key Lab Intraocular Tumor Diag & Treatmen, Beijing Tongren Eye Ctr,Beijing Tongren Hosp, 1 Dong Jiao Min Xiang, Beijing 100730, Peoples R China
[4] Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany
基金
中国国家自然科学基金; 北京市自然科学基金;
关键词
Optical coherence tomography angiography; OCT angiography; Central serous chorioretinopathy; Photodynamic therapy; Indocyanine green angiography; INDOCYANINE GREEN ANGIOGRAPHY; FLUORESCEIN ANGIOGRAPHY; OCT ANGIOGRAPHY; NEOVASCULARIZATION;
D O I
10.1007/s00417-019-04318-x
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PurposeTo study the changes in the choroidal vascular pattern of the deep choroidal layer and choriocapillaris in the eyes with central serous chorioretinopathy (CSC) before versus after photodynamic therapy (PDT) as visualized by optical coherence tomography angiography (OCTA).MethodsThis comparative case series study included patients who underwent a half-dose of PDT as a therapy for CSC. Using OCTA and manually shifting the reference level into the deep choroidal layer, we assessed the density of the deep choroidal vascular layer and choriocapillaris.ResultsThe study included 20 patients (17 men; mean age, 43.310.9years), with two patients showing bilateral CSC. In the eyes affected by CSC, the mean vascular density of the deep choroidal layer and choriocapillaris increased significantly from 54.2 +/- 6.7% at baseline to 58.0 +/- 4.7% at 1month after PDT (P=0.002) and from 58.1 +/- 2.7% at baseline to 60.5 +/- 2.7% at 1month after PDT (P=0.004), respectively. The difference between affected and unaffected eyes was significantly larger at baseline than at 1month after PDT (deep choroidal layer 4.79 +/- 6.02 versus 0.39 +/- 3.46, P=0.002; choriocapillaris 4.26 +/- 3.94 versus 1.25 +/- 3.44, P=0.002) and larger than at 3months after baseline (n=11 patients), when the affected and unaffected fellow eyes no longer differed significantly (P=0.66 and P=0.37, respectively). As a corollary, the width of the large choroidal vessels in the deep choroidal layer decreased after the PDT. Comparing assessments by two blinded examiners revealed a kappa value of 0.90, indicating a good agreement for examination of the deep choroidal layer.Conclusion p id=Par4 In conclusion, OCTA can be helpful to visualize the deep choroidal vascular layer by manually shifting the reference layer deeper into the choroid.
引用
收藏
页码:1365 / 1372
页数:8
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