Mechanisms of Tumor Development and Anti-angiogenic Therapy in Glioblastoma Multiforme

被引：25
|
作者：
Onishi, Manabu [1 ]
Kurozumi, Kazuhiko [1 ]
Ichikawa, Tomotsugu [1 ]
Date, Isao [1 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg, Okayama 7008558, Japan
来源：
NEUROLOGIA MEDICO-CHIRURGICA | 2013年 / 53卷 / 11期
关键词：
cilengitide; bevacizumab; angiogenesis; invasion; GELATINASE-B MMP-9; BRAIN-TUMORS; INTEGRIN ALPHA(V)BETA(3); RECURRENT GLIOBLASTOMA; ENDOTHELIAL-CELLS; MALIGNANT GLIOMAS; SINGLE-AGENT; PHASE-II; IN-VIVO; CILENGITIDE;
D O I：
10.2176/nmc.ra2013-0200
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Despite advances in surgical and medical therapy, glioblastoma multiforme (GBM) remains a fatal disease. There has been no significant increase in survival for patients with this disease over the last 20 years. Tumor vasculature formation and glioma cell invasion along the white matter tracts both play a pivotal role in glioma development. Angiogenesis and invasion are the major factors believed to be responsible for treatment resistance in tumors, and a better understanding of the glioma invasion and angiogenesis mechanisms will lead to the development of potential new treatments. In this review, we focus on the molecular characteristics of angiogenesis and invasion in human malignant glioma. We discuss bevacizumab and cilengitide, which are used to inhibit angiogenesis in GBM.
引用
收藏
页码：755 / 763
页数：9
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