Carboplatin Rechallenge After Hypersensitivity Reactions in Pediatric Patients With Low-Grade Glioma

被引:12
作者
Shah, Amish C. [1 ]
Minturn, Jane E. [1 ,2 ]
Li, Yimei [1 ,3 ]
Belasco, Jean B. [1 ,2 ]
Phillips, Peter C. [1 ,2 ]
Kang, Tammy I. [1 ,2 ]
Cole, Kristina A. [1 ,2 ]
Waanders, Angela J. [1 ,2 ]
Pollack, Rosanna [1 ]
Didomenico, Concetta [1 ]
Wildes, Cynthia [1 ]
Fisher, Michael J. [1 ,2 ]
机构
[1] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA
关键词
allergic reaction; carboplatin; desensitization; hypersensitivity; low-grade glioma; rechallenge; CHILDHOOD-CANCER SURVIVOR; BRAIN-TUMOR CONSORTIUM; PHASE-II; CHILDREN; CHEMOTHERAPY; MALIGNANCIES; RECURRENT; TEMOZOLOMIDE; LEUKEMIA; THERAPY;
D O I
10.1002/pbc.25697
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundThe high prevalence of carboplatin hypersensitivity reactions (HSR) significantly affects the treatment of pediatric patients with low-grade glioma (LGG). Rechallenging patients is an option that must balance the risks of repeat allergic reaction to the benefits of retaining an effective anti-tumor regimen. ProcedureWe performed a retrospective review of children with LGG treated with carboplatin and vincristine between October 2000 and April 2013, who had a documented HSR to carboplatin. Patients were re-exposed to carboplatin using either precautionary measures (prolonged infusion time and premedication with H1 antagonists, H2 antagonists, and corticosteroids), a desensitization protocol, or both. ResultsWe report the results of our institutional experience of carboplatin re-exposure using both premedication with a prolonged infusion time and a desensitization protocol. Overall, 40 of 55 (73%) patients were successfully rechallenged with carboplatin, including 19 of 25 (76%) patients who underwent desensitization. ConclusionOur results demonstrate re-exposure to be a safe alternative to abandoning carboplatin for patients with a hypersensitivity reaction. We propose a clinical algorithm for treatment. Pediatr Blood Cancer 2015; 9999:1-6 (c) 2015 Wiley Periodicals, Inc.
引用
收藏
页码:21 / 26
页数:6
相关论文
共 21 条
[11]   Efficacy of bevacizumab plus irinotecan in children with recurrent Low-grade gliomas-a Pediatric Brain Tumor Consortium study [J].
Gururangan, Sridharan ;
Fangusaro, Jason ;
Poussaint, Tina Young ;
McLendon, Roger E. ;
Onar-Thomas, Arzu ;
Wu, Shengjie ;
Packer, Roger J. ;
Banerjee, Anu ;
Gilbertson, Richard J. ;
Fahey, Frederic ;
Vajapeyam, Sridhar ;
Jakacki, Regina ;
Gajjar, Amar ;
Goldman, Stewart ;
Pollack, Ian F. ;
Friedman, Henry S. ;
Boyett, James M. ;
Fouladi, Maryam ;
Kun, Larry E. .
NEURO-ONCOLOGY, 2014, 16 (02) :310-317
[12]   Temozolomide in pediatric low-grade glioma [J].
Khaw, Seong L. ;
Coleman, Lee T. ;
Downie, Peter A. ;
Heath, John A. ;
Ashley, David M. .
PEDIATRIC BLOOD & CANCER, 2007, 49 (06) :808-811
[13]   Carboplatin hypersensitivity reaction in pediatric patients with low-grade glioma - A Canadian pediatric brain tumor consortium experience [J].
Lafay-Cousin, Lucie ;
Sung, Lillian ;
Carret, Anne-Sophie ;
Hukin, Juliette ;
Wilson, Beverly ;
Johnston, Donna L. ;
Zelcer, Shayna ;
Silva, Mariana ;
Odarne, Isaac ;
Mpofu, Chris ;
Strother, Douglas ;
Bouffet, Eric .
CANCER, 2008, 112 (04) :892-899
[14]   Hypersensitivity reactions to carboplatin in children [J].
Lazzareschi, I ;
Ruggiero, A ;
Riccardi, R ;
Attinà, G ;
Colosimo, C ;
Lasorella, A .
JOURNAL OF NEURO-ONCOLOGY, 2002, 58 (01) :33-37
[15]   Carboplatin hypersensitivity: a 6-h 12-step protocol effective in 35 desensitizations in patients with gynecological malignancies and mast cell/IgE-mediated reactions [J].
Lee, CW ;
Matulonis, UA ;
Castells, MC .
GYNECOLOGIC ONCOLOGY, 2004, 95 (02) :370-376
[16]   Phase II Trial of Conformal Radiation Therapy for Pediatric Low-Grade Glioma [J].
Merchant, Thomas E. ;
Kun, Larry E. ;
Wu, Shengjie ;
Xiong, Xiaoping ;
Sanford, Robert A. ;
Boop, Frederick A. .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (22) :3598-3604
[17]   Secondary hematological malignancies associated with temozolomide in patients with glioma [J].
Momota, Hiroyuki ;
Narita, Yoshitaka ;
Miyakita, Yasuji ;
Shibui, Soichiro .
NEURO-ONCOLOGY, 2013, 15 (10) :1445-1450
[18]   CARBOPLATIN AND VINCRISTINE FOR RECURRENT AND NEWLY DIAGNOSED LOW-GRADE GLIOMAS OF CHILDHOOD [J].
PACKER, RJ ;
LANGE, B ;
ATER, J ;
NICHOLSON, HS ;
ALLEN, J ;
WALKER, R ;
PRADOS, M ;
JAKACKI, R ;
REAMAN, G ;
NEEDLES, MN ;
PHILLIPS, PC ;
RYAN, J ;
BOYETT, JM ;
GEYER, R ;
FINLAY, J .
JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (05) :850-856
[19]   Treatment of pediatric low-grade gliomas with a nitrosourea-based multiagent chemotherapy regimen [J].
Prados, MD ;
Edwards, MSB ;
Rabbitt, J ;
Lamborn, K ;
Davis, RL ;
Levin, VA .
JOURNAL OF NEURO-ONCOLOGY, 1997, 32 (03) :235-241
[20]  
Schiavetti A, 1999, MED PEDIATR ONCOL, V32, P183, DOI 10.1002/(SICI)1096-911X(199903)32:3<183::AID-MPO4>3.0.CO