Spectrophotometric Methods for Determination of Dopamine Hydrochloride in Bulk and in Injectable Forms

被引：12
作者：
Al-Salahi, Najat O. A. [1 ]
Hashem, Elham Y. [2 ]
Abdel-Kader, Doaa A. [2 ]
机构：
[1] Abyan Univ, Fac Sci, Chem Dept, Aden, Yemen
[2] Assiut Univ, Fac Sci, Chem Dept, Assiut 71516, Egypt
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2022年 / 278卷
关键词：
Dopamine hydrochloride; Pharmaceutical Formulations; UV spectrophotometry; Oxidation; Potassium permanganate or KMnO4; CATECHOLAMINES; RECEPTORS; ELECTRODE; SAMPLES; ASSAY;
D O I：
10.1016/j.saa.2022.121278
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Two highly simple, economical, accurate and sensitive spectrophotometric methods for determination of dopamine hydrochloride (DAH) in either pure form and pharmaceutical formulations are described. The first method is based on determination of (DAH) spectrophotometrically at maximum absorbance 280 nm (method A). The second one is based on reduction of alkaline KMnO4 by (DAH) leading to the formation of green manganate species which are measured at 610 nm (method B). Under optimized conditions, the calibration graphs were linear in the range of 3.793 - 45.513, 0.190 - 4.362 mu g.mL(-1) of (DAH) for methods A and B respectively. The developed methods were successfully applied for the determination of dopamine hydrochloride in pharmaceutical samples.Published by Elsevier B.V.
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页数：7
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