Mapping quantitative trait loci with epistatic effects

被引:58
作者
Yi, NJ [1 ]
Xu, SZ [1 ]
机构
[1] Univ Calif Riverside, Dept Bot & Plant Sci, Riverside, CA 92521 USA
关键词
D O I
10.1017/S0016672301005511
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Epistatic variance can be an important source of variation for complex traits. However, detecting epistatic effects is difficult primarily due to insufficient sample sizes and lack of robust statistical methods. In this paper, we develop a Bayesian method to map multiple quantitative trait loci (QTLs) with epistatic effects. The method can map QTLs in complicated mating designs derived from the cross of two inbred lines. In addition to mapping QTLs for quantitative traits, the proposed method can even map genes underlying binary traits such as disease susceptibility using the threshold model. The parameters of interest are various QTL effects, including additive, dominance and epistatic effects of QTLs, the locations of identified QTLs and even the number of QTLs. When the number of QTLs is treated as an unknown parameter, the dimension of the model becomes a variable. This requires the reversible jump Markov chain Monte Carlo algorithm. The utility of the proposed method is demonstrated through analysis of simulation data.
引用
收藏
页码:185 / 198
页数:14
相关论文
共 33 条
[1]   BAYESIAN-ANALYSIS OF BINARY AND POLYCHOTOMOUS RESPONSE DATA [J].
ALBERT, JH ;
CHIB, S .
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1993, 88 (422) :669-679
[2]  
[Anonymous], 1998, Genetics and Analysis of Quantitative Traits (Sinauer)
[3]  
BROOKS SP, 1998, CONVERVENCE ASSESSME
[4]  
Bulmer M. G., 1980, MATH THEORY QUANTITA
[5]  
Carlborg Ö, 2000, GENETICS, V155, P2003
[6]  
CHURCHILL GA, 1994, GENETICS, V138, P963
[7]  
Devroye L., 1986, NONUNIFORM RANDOM VA
[8]   STOCHASTIC RELAXATION, GIBBS DISTRIBUTIONS, AND THE BAYESIAN RESTORATION OF IMAGES [J].
GEMAN, S ;
GEMAN, D .
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE, 1984, 6 (06) :721-741
[9]  
Green PJ, 1995, BIOMETRIKA, V82, P711, DOI 10.2307/2337340
[10]   A SIMPLE REGRESSION METHOD FOR MAPPING QUANTITATIVE TRAIT LOCI IN LINE CROSSES USING FLANKING MARKERS [J].
HALEY, CS ;
KNOTT, SA .
HEREDITY, 1992, 69 :315-324