Physicochemical properties of radiographic contrast media, potential nephrotoxicity and prophylaxis

被引：6

作者：

Hogstrom, Barry ^{[1
]}

Ikei, Nobuhiro ^{[2
]}

机构：

[1] Otsuka Pharmaceut Dev & Commercializat, Med Imaging, Otsuka Novel Prod, Princeton, NJ 08540 USA

[2] Otsuka Pharmaceut Co Ltd, Otsuka Int Asia Arab Div, Osaka, Japan

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2015年 / 42卷 / 12期

关键词：

contrast induced nephropathy; contrast media; creatinine; glomerular filtration rate; osmolality; viscosity; ACUTE KIDNEY INJURY; PERCUTANEOUS CORONARY INTERVENTION; GELATINASE-ASSOCIATED LIPOCALIN; PERSISTENT RENAL DYSFUNCTION; HIGH-RISK PATIENTS; INDUCED NEPHROPATHY; SODIUM-BICARBONATE; N-ACETYLCYSTEINE; NITRIC-OXIDE; RADIOCONTRAST NEPHROPATHY;

D O I：

10.1111/1440-1681.12487

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Contrast induced nephropathy (CIN) remains a controversial topic. The clinical relevance of changes in laboratory parameters has been challenged; some authors have even suggested that CIN simply reflects natural fluctuations. Other areas of controversy include the pathophysiology of CIN, effectiveness of prophylactic approaches and differences in nephrotoxicity between individual contrast media (CM). The aim of this review is to summarize the current understanding of laboratory findings and explore its relationship to CM toxicity.

引用

页码：1251 / 1257

页数：7

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