Synthesis, Reactivity, and Catalytic Applications of Isolable (NHC)Cu(CHF2) Complexes

被引：70

作者：

Bour, James R. ^{[1
]}

Kariofillis, Stavros K. ^{[1
]}

Sanford, Melanie S. ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, 930 North Univ Ave, Ann Arbor, MI 48109 USA

来源：

ORGANOMETALLICS | 2017年 / 36卷 / 07期

基金：

美国国家科学基金会;

关键词：

COPPER-MEDIATED DIFLUOROMETHYLATION; BURIED VOLUME; ARYL BROMIDES; HALIDES; TRIFLUOROMETHYLATION; ALLYLATION; LIGANDS; IODIDES; ACCESS;

D O I：

10.1021/acs.organomet.7b00025

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Difluoromethyl copper complexes have been proposed as key intermediates in a variety of Cu-catalyzed difluoromethylation reactions. However, studies of these putative intermediates have been impeded by the low stability of these [Cu(CHF2)] species. This report describes the synthesis of isolable N-heterocyclic carbene ligated copper(I) difluoromethyl complexes. The stoichiometric reactions of these complexes with aryl electrophiles (i.e., diaryliodonium salts, aryl iodides, and aryl bromides) are described. In addition, N-heterocyclic carbene copper(I) species are demonstrated to serve as catalysts for the cross-coupling of aryl iodides with (difluoromethyl)trimethylsilane to afford difluoromethyl arene products.

引用

页码：1220 / 1223

页数：4

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