Novel 4-anilino-α-carboline derivatives induce cell death in nonadhesive breast cancer cells through inhibition of Brk activity

被引：5
|
作者：
Oelze, Markus [1 ]
Mahmoud, Kazem Ahmed [2 ]
Sippl, Wolfgang [2 ]
Wersig, Tom [2 ]
Hilgeroth, Andreas [2 ]
Ritter, Christoph A. [1 ]
机构：
[1] Ernst Moritz Arndt Univ Greifswald, Inst Pharm, Clin Pharm, Friedrich Ludwig Jahn Str 17, D-17489 Greifswald, Germany
[2] Univ Halle Wittenberg, Inst Pharm Pharmaceut & Med Chem, D-06108 Halle, Germany
来源：
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | 2015年 / 53卷 / 12期
关键词：
breast cancer; Brk; small molecule inhibitors; loss of adherence; cell death; TUMOR KINASE; PROLIFERATION; ACTIVATION; MIGRATION;
D O I：
10.5414/CPXCES14EA07
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
[No abstract available]
引用
收藏
页码：1052 / 1055
页数：4
相关论文
共 50 条
  • [21] Goji berry fruit extracts induce cytotoxicity and apoptotic cell death in breast cancer cells
    Gezici, Sevgi
    JOURNAL OF RESEARCH IN PHARMACY, 2023, 27 (05): : 1751 - 1759
  • [22] Chitosan-stabilized platinum nanoparticles induce apoptotic cell death in breast cancer cells
    Ramanathan, Elakkiya
    Ponnuchamy, Kumar
    Muthusamy, Govarthanan
    Varatharajan, Nithya
    Sabapathi, Durgadevi
    Selvaraj, Anitha
    APPLIED NANOSCIENCE, 2022, 13 (6) : 3867 - 3873
  • [23] Synthetic polysulfane derivatives induce cell cycle arrest and apoptotic cell death in human hematopoietic cancer cells
    Czepukojc, Brigitte
    Baltes, Anne-Kathrin
    Cerella, Claudia
    Kelkel, Mareike
    Viswanathan, Uma M.
    Salm, Franz
    Burkholz, Torsten
    Schneider, Carolin
    Dicato, Mario
    Montenarh, Mathias
    Jacob, Claus
    Diederich, Marc
    FOOD AND CHEMICAL TOXICOLOGY, 2014, 64 : 249 - 257
  • [24] FGFR inhibition results in a novel mechanism of cell death in endometrial cancer cells
    Byron, Sara
    Gartside, Michael
    Williams, Jasmaine
    Wellens, Candice
    Pollock, Pamela
    CANCER RESEARCH, 2009, 69
  • [25] Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKβ
    A-Mi Seo
    Seung-Woo Hong
    Jae-Sik Shin
    In-Chul Park
    Nam-Joo Hong
    Dae-Jin Kim
    Won-Keun Lee
    Wang-Jae Lee
    Dong-Hoon Jin
    Myeong-Sok Lee
    Apoptosis, 2009, 14 : 913 - 922
  • [26] Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKβ
    Seo, A-Mi
    Hong, Seung-Woo
    Shin, Jae-Sik
    Park, In-Chul
    Hong, Nam-Joo
    Kim, Dae-Jin
    Lee, Won-Keun
    Lee, Wang-Jae
    Jin, Dong-Hoon
    Lee, Myeong-Sok
    APOPTOSIS, 2009, 14 (07) : 913 - 922
  • [27] HUMAN BREAST CANCER CELLS INDUCE OSTEOCLASTOGENESIS AND ENDOTHELIAL CELL PROLIFERATION IN VITRO AND ARE AFFECTED BY INHIBITION OF C-SRC ACTIVITY
    Fortunati, Dario
    Recchia, Irene
    Susa, Mira
    Fabbro, Doriano
    Di Giacinto, Claudia
    Teti, Anna
    Rucci, Nadia
    CALCIFIED TISSUE INTERNATIONAL, 2004, 74 : S110 - S110
  • [28] Synthesis and anticancer activity of novel Eugenol derivatives against breast cancer cells
    Alam, Mohammad Mahboob
    NATURAL PRODUCT RESEARCH, 2023, 37 (10) : 1632 - 1640
  • [29] Azole antifungal drugs induce cell death by suppressing mTOR through PI3K/Akt inhibition in human breast cancer
    Park, Ju Ho
    Kim, Hyesook
    Kim, So Hee
    CANCER RESEARCH, 2018, 78 (13)
  • [30] Estrogen receptor α mediates breast cancer cell resistance to paclitaxel through inhibition of apoptotic cell death
    Sui, Meihua
    Huang, Yi
    Park, Ben Ho
    Davidson, Nancy E.
    Fan, Weimin
    CANCER RESEARCH, 2007, 67 (11) : 5337 - 5344
12345