Spectroscopic, thermal and biological studies of coordination compounds of sulfasalazine drug: Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) transition metal complexes

The complexations of sulfasalazine (H(3)Suz) with sonic of transition metals have been investigated. Three types of complexes, [Mn(HSuz)(-2)(H2O)(4)]center dot 2H(2)O, [M(HSuz)(-2)(H2O)(2)]center dot xH(2)O (M = Hg(II), ZrO(II) and VO(II), x = 4, 8 and 6, respectively) and [M(HSuz)(-2)(Cl)(H2O)(3)]center dot xH(2)O (M = Cr(III) and Y(III), x = 5 and 6, respectively) were obtained and characterized by physicochernical. and spectroscopic methods. The IR spectra of the complexes suggest that the sulfasalazine behaves as a monoanionic bidentate ligand. The thermal decomposition of the complexes as well as thermodynamic parameters (Delta E*, Delta H*, Delta S* and Delta G*) were estimated using Coats-Redfern and Horowitz-Metzger equations. In vitro antimicrobial activities of the H(3)Suz and the complexes were tested.