Third Trimester Vitamin D Status Is Associated With Birth Outcomes and Linear Growth of HIV-Exposed Uninfected Infants in the United States

被引：6

作者：

Sudfeld, Christopher R. ^{[1
]}

Jacobson, Denise L. ^{[2
]}

Rueda, Noe M. ^{[3
]}

Neri, Daniela ^{[4
]}

Mendez, Armando J. ^{[5
]}

Butler, Laurie ^{[6
]}

Siminski, Suzanne ^{[6
]}

Hendricks, Kristy M. ^{[7
]}

Mellins, Claude A. ^{[8
,9
]}

Duggan, Christopher P. ^{[1
,10
,11
,12
]}

Miller, Tracie L. ^{[6
]}

Chadwick, Ellen ^{[13
]}

Sanders, Margaret Ann ^{[13
]}

Malee, Kathleen ^{[13
]}

Hunter, Scott ^{[13
]}

Shearer, William ^{[14
]}

Paul, Mary ^{[14
]}

Cooper, Norma ^{[14
]}

Harris, Lynnette ^{[14
]}

Purswani, Murli ^{[15
]}

Stuard, Emma ^{[15
]}

Baig, Mahboobullah Mirza ^{[15
]}

Villegas, Alma ^{[15
]}

Puga, Ana

Cooley, Dia ^{[16
]}

Garvie, Patricia A. ^{[16
]}

Blood, James ^{[16
]}

Borkowsky, William ^{[17
]}

Deygoo, Sandra ^{[17
]}

Vasserman, Marsha ^{[17
]}

Dieudonne, Arry ^{[18
]}

Bettica, Linda ^{[18
]}

Johnson, Juliette ^{[18
]}

Knapp, Katherine ^{[19
]}

Allison, Kim ^{[19
]}

Wilkins, Megan ^{[19
]}

Russell-Bell, Jamie ^{[19
]}

Rosario, Nicolas ^{[20
]}

Angeli-Nieves, Lourdes ^{[20
]}

Olivera, Vivian ^{[20
]}

Kohlhoff, Stephan ^{[21
]}

Dennie, Ava ^{[21
]}

Ben-Israel, Ady ^{[21
]}

Kaye, Jean ^{[21
]}

Van Dyke, Russell ^{[22
]}

Craig, Karen ^{[22
]}

Sirois, Patricia ^{[22
]}

Crain, Marilyn ^{[23
]}

Hickman, Paige ^{[23
]}

Marullo, Dan ^{[23
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA

[2] Harvard TH Chan Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA USA

[3] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA

[4] Univ Sao Paulo, Ctr Epidemiol Res Nutr & Hlth, Sao Paulo, Brazil

[5] Univ Miami, Leonard M Miller Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Miami, FL USA

[6] Frontier Sci Technol Res Fdn INC, Amherst Off, Amherst, NY USA

[7] Gessel Sch Med Dartmouth, Lebanon, NH USA

[8] HIV Ctr Clin & Behav Studies, New York State Psychiat Inst, New York, NY USA

[9] Columbia Univ, New York, NY USA

[10] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[11] Boston Childrens Hosp, Dept Div Gastroenterol Hepatol & Nutr, Boston, MA USA

[12] Harvard Med Sch, Boston, MA 02115 USA

[13] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL USA

[14] Baylor Coll Med, Houston, TX 77030 USA

[15] Bronx Lebanon Hosp Ctr, Bronx, NY 10456 USA

[16] Childrens Diagnost Treatment Ctr, Ft Lauderdale, FL USA

[17] NYU, Sch Med, New York, NY 10003 USA

[18] Rutgers New Jersey Med Sch, Newark, NJ USA

[19] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA

[20] San Juan Hosp, Dept Pediat, San Juan, PR USA

[21] Suny Downstate Med Ctr, New York, NY USA

[22] Tulane Univ, Sch Med, New Orleans, LA 70118 USA

[23] Univ Alabama, Birmingham, W Midlands, England

[24] Univ Calif San Diego, San Diego, CA 92103 USA

[25] Univ Colorado, Denver, CO 80202 USA

[26] Univ Florida, Ctr HIV AIDS Res, Educ & Serv, Gainesville, FL 32611 USA

[27] Univ Illinois, Chicago, IL USA

[28] Univ Southern Calif, Keck Med, Los Angeles, CA 90089 USA

[29] Univ Puerto Rico, Sch Med, Med Sci Campus, San Juan, PR 00936 USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2019年 / 81卷 / 03期

关键词：

HIV; pregnancy; vitamin D; nutrition; micronutrients; HUMAN-IMMUNODEFICIENCY-VIRUS; GESTATIONAL-AGE; D DEFICIENCY; WEIGHT; CHILDREN; PRETERM; MORBIDITY; PREGNANCY; STANDARDS; WOMEN;

D O I：

10.1097/QAI.0000000000002041

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Vitamin D status in pregnancy may influence the risk of prematurity, birth size, and child postnatal growth, but few studies have examined the relationship among pregnant women living with HIV. Methods: We conducted a prospective cohort study of 257 HIV-infected mothers and their HIV-exposed uninfected infants who were enrolled in the 2009-2011 nutrition substudy of the Surveillance Monitoring for ART Toxicities (SMARTT) study. HIV-infected pregnant women had serum 25-hydroxyvitamin D (25(OH) D) assessed in the third trimester of pregnancy, and their infants' growth and neurodevelopment were evaluated at birth and approximately 1 year of age. Results: The mean third trimester serum 25(OH) D concentration was 35.4 +/- 14.2 ng/mL with 15% of women classified as vitamin D deficient (< 20 ng/mL) and 21% as insufficient (20-30 ng/mL). In multivariable models, third trimester vitamin D deficiency and insufficiency were associated with 2273 g [95% confidence interval (CI): 2450 to 297] and 2203 g (95% CI: 2370 to 235) lower birth weights compared with vitamin D sufficient women, respectively. Maternal vitamin D deficiency was also associated with shorter gestation (mean difference 20.65 weeks; 95% CI: 21.22 to 20.08) and lower infant length-for-age z-scores at 1 year of age (mean difference: 20.65; 95% CI: 21.18 to 20.13). We found no association of vitamin D status with infant neurodevelopment at 1 year of age. Conclusion: Third trimester maternal vitamin D deficiency was associated with lower birth weight, shorter length of gestation, and reduced infant linear growth. Studies and trials of vitamin D supplementation in pregnancy for women living with HIV are warranted.

引用

页码：336 / 344

页数：9

共 48 条

[1] Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Low Birth Weight Children [J].

Aarnoudse-Moens, Cornelieke Sandrine Hanan ;

Weisglas-Kuperus, Nynke ;

van Goudoever, Johannes Bernard ;

Oosterlaan, Jaap .

PEDIATRICS, 2009, 124 (02) :717-728

[2] HIV-exposed uninfected children: a growing population with a vulnerable immune system? [J].

Afran, L. ;

Knight, M. Garcia ;

Nduati, E. ;

Urban, B. C. ;

Heyderman, R. S. ;

Rowland-Jones, S. L. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2014, 176 (01) :11-22

[3] Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies [J].

Aghajafari, Fariba ;

Nagulesapillai, Tharsiya ;

Ronksley, Paul E. ;

Tough, Suzanne C. ;

O'Beirne, Maeve ;

Rabi, Doreen M. .

BMJ-BRITISH MEDICAL JOURNAL, 2013, 346

[4]

[Anonymous], BMJ OPEN, DOI DOI 10.1136/BMJOPEN-2017-016404

[5]

[Anonymous], 2006, ACTA PAEDIATR, V450, P1, DOI DOI 10.1080/08035320500495548

[6] EVALUATION OF THE NEWBORN INFANT-2ND REPORT [J].

APGAR, V ;

HOLADAY, DA ;

JAMES, LS ;

WEISBROT, IM ;

BERRIEN, C .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1958, 168 (15) :1985-1988

[7] Vitamin D: modulator of the immune system [J].

Baeke, Femke ;

Takiishi, Tatiana ;

Korf, Hannelie ;

Gysemans, Conny ;

Mathieu, Chantal .

CURRENT OPINION IN PHARMACOLOGY, 2010, 10 (04) :482-496

[8]

Bayley N., 2005, Bayley scales of infant and toddler development, V3rd

[9] Inflammatory processes in preterm and term parturition [J].

Christiaens, Inge ;

Zaragoza, Dean B. ;

Guilbert, Larry ;

Robertson, Sarah A. ;

Mitchell, Bryan F. ;

Olson, David M. .

JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2008, 79 (01) :50-57

[10] Low maternal vitamin D status in pregnancy increases the risk of childhood obesity [J].

Daraki, V. ;

Roumeliotaki, T. ;

Chalkiadaki, G. ;

Katrinaki, M. ;

Karachaliou, M. ;

Leventakou, V. ;

Vafeiadi, M. ;

Sarri, K. ;

Vassilaki, M. ;

Papavasiliou, S. ;

Kogevinas, M. ;

Chatzi, L. .

PEDIATRIC OBESITY, 2018, 13 (08) :467-475

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