Atezolizumab and bevacizumab combination compared with sorafenib as the first-line systemic treatment for patients with unresectable hepatocellular carcinoma: A cost-effectiveness analysis in China and the United states
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作者:
Wen, Feng
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Sichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
Sichuan Univ, West China Biostat & Cost Benefit Anal Ctr, Chengdu, Peoples R ChinaSichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
Wen, Feng
[1
,2
]
Zheng, Hanrui
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Sichuan Univ, West China Biostat & Cost Benefit Anal Ctr, Chengdu, Peoples R China
Sichuan Univ, West China Hosp, Dept Clin Pharm, Chengdu, Peoples R ChinaSichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
Zheng, Hanrui
[2
,3
]
Zhang, Pengfei
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Sichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
Sichuan Univ, West China Biostat & Cost Benefit Anal Ctr, Chengdu, Peoples R ChinaSichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
Zhang, Pengfei
[1
,2
]
Liao, Weiting
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Sichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
Sichuan Univ, West China Biostat & Cost Benefit Anal Ctr, Chengdu, Peoples R ChinaSichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
Liao, Weiting
[1
,2
]
Zhou, Kexun
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Sichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
Sichuan Univ, West China Biostat & Cost Benefit Anal Ctr, Chengdu, Peoples R ChinaSichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
Zhou, Kexun
[1
,2
]
Li, Qiu
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Sichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
Sichuan Univ, West China Biostat & Cost Benefit Anal Ctr, Chengdu, Peoples R ChinaSichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
Li, Qiu
[1
,2
]
机构:
[1] Sichuan Univ, West China Hosp, Dept Med Oncol, Ctr Canc, Chengdu, Peoples R China
[2] Sichuan Univ, West China Biostat & Cost Benefit Anal Ctr, Chengdu, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Clin Pharm, Chengdu, Peoples R China
atezolizumab and bevacizumab;
cost‐
effectiveness;
first‐
line systemic treatment;
unresectable hepatocellular carcinoma;
PRIMARY LIVER-CANCER;
HEPATITIS-B-VIRUS;
THERAPIES;
D O I:
10.1111/liv.14795
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
Background & Aims In patients with unresectable hepatocellular carcinoma (HCC), the combination of atezolizumab and bevacizumab improved progression-free survival (PFS) and overall survival compared with sorafenib in the IMbrave150 trial. However, whether the price of the combination could be affordable is unknown. The current study assessed the cost-effectiveness of the combination of atezolizumab and bevacizumab as first-line systemic therapy for patients with unresectable HCC from the Chinese and American payers' perspective. Methods A Markov model was built based on a global, multicentre, open-label, phase III randomized trial (IMbrave150, NCT03434379) that included three states of the patient's health: stable disease (SD), progressive disease (PD) and death. Data for all medical costs were acquired from the Red Book, published literature and West China Hospital. Quality-adjusted life years (QALYs) and incremental cost-effectiveness ratios (ICERs) were the primary outcomes. Sensitivity analyses were performed to evaluate the model uncertainty. Results The treatment consisting of a combination of atezolizumab and bevacizumab yielded an additional 0.53 QALYs compared with sorafenib alone, leading to an ICER of $145,546.21 per QALY in China and $168,030.21 per QALY in the USA, both beyond the willing-to-pay threshold ($28,527.00/QALY in China and $150,000.00 /QALY in the USA). The utility of the PD state was the most influential factor in the Chinese model, and the American model was the most sensitive to the price of sorafenib. The results of the models were robust across sensitivity analyses. Conclusion The combination of atezolizumab and bevacizumab was not a cost-effective strategy for the first-line systemic treatment of unresectable HCC from the Chinese and American payers' perspective.
机构:
Hyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Japanese Red Cross Soc Himeji Hosp, Dept Gastroenterol, Himeji, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Tada, Toshifumi
Kumada, Takashi
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Gifu Kyoritsu Univ, Dept Nursing, Ogaki, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Kumada, Takashi
Hiraoka, Atsushi
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Ehime Prefectural Cent Hosp, Gastroenterol Ctr, Matsuyama, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Hiraoka, Atsushi
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Hirooka, Masashi
Kariyama, Kazuya
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Okayama City Hosp, Dept Gastroenterol, Okayama, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Kariyama, Kazuya
Tani, Joji
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Kagawa Univ, Dept Gastroenterol & Hepatol, Takamatsu, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Tani, Joji
Atsukawa, Masanori
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Nippon Med Sch, Dept Internal Med, Div Gastroenterol & Hepatol, Tokyo, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Atsukawa, Masanori
Takaguchi, Koichi
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Kagawa Prefectural Cent Hosp, Dept Hepatol, Takamatsu, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Takaguchi, Koichi
Itobayashi, Ei
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Asahi Gen Hosp, Dept Gastroenterol, Asahi, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Itobayashi, Ei
Fukunishi, Shinya
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Osaka Med & Pharmaceut Univ, Dept Gastroenterol, Osaka, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Fukunishi, Shinya
Tsuji, Kunihiko
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Teine Keijinkai Hosp, Ctr Gastroenterol, Sapporo, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Tsuji, Kunihiko
Ishikawa, Toru
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Saiseikai Niigata Hosp, Dept Gastroenterol, Niigata, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Ishikawa, Toru
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Tajiri, Kazuto
Ochi, Hironori
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Japanese Red Cross Matsuyama Hosp, Hepatobiliary Ctr, Matsuyama, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Ochi, Hironori
Yasuda, Satoshi
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Ogaki Municipal Hosp, Dept Gastroenterol & Hepatol, Ogaki, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Yasuda, Satoshi
Toyoda, Hidenori
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Ogaki Municipal Hosp, Dept Gastroenterol & Hepatol, Ogaki, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Toyoda, Hidenori
Ogawa, Chikara
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Japanese Red Cross Takamatsu Hosp, Dept Gastroenterol, Takamatsu, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Ogawa, Chikara
Nishimura, Takashi
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Hyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Nishimura, Takashi
Hatanaka, Takeshi
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Gunma Saiseikai Maebashi Hosp, Dept Gastroenterol, Maebashi, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Hatanaka, Takeshi
Kakizaki, Satoru
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Natl Hosp Org Takasaki Gen Med Ctr, Dept Clin Res, Takasaki, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Kakizaki, Satoru
Shimada, Noritomo
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Otakanomori Hosp, Div Gastroenterol & Hepatol, Kashiwa, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Shimada, Noritomo
Kawata, Kazuhito
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Hamamatsu Univ, Dept Hepatol, Sch Med, Hamamatsu, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Kawata, Kazuhito
Tada, Fujimasa
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Ehime Prefectural Cent Hosp, Gastroenterol Ctr, Matsuyama, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Tada, Fujimasa
Ohama, Hideko
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Ehime Prefectural Cent Hosp, Gastroenterol Ctr, Matsuyama, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Ohama, Hideko
Nouso, Kazuhiro
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Okayama City Hosp, Dept Gastroenterol, Okayama, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Nouso, Kazuhiro
Morishita, Asahiro
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Kagawa Univ, Dept Gastroenterol & Hepatol, Takamatsu, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Morishita, Asahiro
Tsutsui, Akemi
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Kagawa Prefectural Cent Hosp, Dept Hepatol, Takamatsu, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Tsutsui, Akemi
Nagano, Takuya
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Kagawa Prefectural Cent Hosp, Dept Hepatol, Takamatsu, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Nagano, Takuya
Itokawa, Norio
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Nippon Med Sch, Dept Internal Med, Div Gastroenterol & Hepatol, Tokyo, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Itokawa, Norio
Okubo, Tomomi
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Nippon Med Sch, Dept Internal Med, Div Gastroenterol & Hepatol, Tokyo, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Okubo, Tomomi
Arai, Taeang
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Nippon Med Sch, Dept Internal Med, Div Gastroenterol & Hepatol, Tokyo, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Arai, Taeang
Imai, Michitaka
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Saiseikai Niigata Hosp, Dept Gastroenterol, Niigata, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Imai, Michitaka
Kosaka, Hisashi
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Kansai Med Univ, Dept Surg, Osaka, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Kosaka, Hisashi
Naganuma, Atsushi
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Natl Hosp Org Takasaki Gen Med Ctr, Dept Gastroenterol, Takasaki, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Naganuma, Atsushi
Matono, Tomomitsu
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Hyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Himeji St Marys Hosp, Dept Internal Med, Himeji, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Matono, Tomomitsu
Koizumi, Yohei
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Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metabol, Matsuyama, Ehime, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Koizumi, Yohei
Nakamura, Shinichiro
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Japanese Red Cross Soc Himeji Hosp, Dept Gastroenterol, Himeji, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Nakamura, Shinichiro
Kaibori, Masaki
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Kansai Med Univ, Dept Surg, Osaka, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Kaibori, Masaki
Iijima, Hiroko
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Hyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
Iijima, Hiroko
Hiasa, Yoichi
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Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metabol, Matsuyama, Ehime, JapanHyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Hyogo, Japan
机构:
Guangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
Peoples Hosp Guangxi Zhuang Autonomous Reg, Nanning, Peoples R ChinaGuangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
Li, Yan
Liang, Xueyan
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Guangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
Peoples Hosp Guangxi Zhuang Autonomous Reg, Nanning, Peoples R ChinaGuangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
Liang, Xueyan
Li, Huijuan
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Guangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
Peoples Hosp Guangxi Zhuang Autonomous Reg, Nanning, Peoples R ChinaGuangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
Li, Huijuan
Yang, Tong
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Guangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
Peoples Hosp Guangxi Zhuang Autonomous Reg, Nanning, Peoples R ChinaGuangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
Yang, Tong
Guo, Sitong
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Guangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
Peoples Hosp Guangxi Zhuang Autonomous Reg, Nanning, Peoples R ChinaGuangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
Guo, Sitong
Chen, Xiaoyu
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Guangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
Peoples Hosp Guangxi Zhuang Autonomous Reg, Nanning, Peoples R ChinaGuangxi Acad Med Sci, Dept Pharm, Nanning, Peoples R China
机构:
Toho Univ, Sch Med, Fac Med, Dept Internal Med Omori,Div Gastroenterol & Hepato, 6-11-1 Omorinishi,Ota Ku, Tokyo 1438541, JapanToho Univ, Sch Med, Fac Med, Dept Internal Med Omori,Div Gastroenterol & Hepato, 6-11-1 Omorinishi,Ota Ku, Tokyo 1438541, Japan
Nagai, Hidenari
Matsuda, Takahisa
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Toho Univ, Sch Med, Fac Med, Dept Internal Med Omori,Div Gastroenterol & Hepato, 6-11-1 Omorinishi,Ota Ku, Tokyo 1438541, JapanToho Univ, Sch Med, Fac Med, Dept Internal Med Omori,Div Gastroenterol & Hepato, 6-11-1 Omorinishi,Ota Ku, Tokyo 1438541, Japan
Matsuda, Takahisa
Igarashi, Yoshinori
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Toho Univ, Sch Med, Fac Med, Dept Internal Med Omori,Div Gastroenterol & Hepato, 6-11-1 Omorinishi,Ota Ku, Tokyo 1438541, JapanToho Univ, Sch Med, Fac Med, Dept Internal Med Omori,Div Gastroenterol & Hepato, 6-11-1 Omorinishi,Ota Ku, Tokyo 1438541, Japan
机构:
Univ Waterloo, Fac Sci, Sch Pharm, 10A Victoria St South, Kitchener, ON N2G 1C5, CanadaUniv Waterloo, Fac Sci, Sch Pharm, 10A Victoria St South, Kitchener, ON N2G 1C5, Canada
Kim, John J.
McFarlane, Thomas
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Univ Waterloo, Fac Sci, Sch Pharm, 10A Victoria St South, Kitchener, ON N2G 1C5, Canada
Sunnybrook Odette Canc Ctr, Toronto, ON, CanadaUniv Waterloo, Fac Sci, Sch Pharm, 10A Victoria St South, Kitchener, ON N2G 1C5, Canada
McFarlane, Thomas
Tully, Stephen
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Univ Waterloo, Fac Sci, Sch Pharm, 10A Victoria St South, Kitchener, ON N2G 1C5, CanadaUniv Waterloo, Fac Sci, Sch Pharm, 10A Victoria St South, Kitchener, ON N2G 1C5, Canada
Tully, Stephen
Wong, William W. L.
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Univ Waterloo, Fac Sci, Sch Pharm, 10A Victoria St South, Kitchener, ON N2G 1C5, CanadaUniv Waterloo, Fac Sci, Sch Pharm, 10A Victoria St South, Kitchener, ON N2G 1C5, Canada