CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer

被引：27

作者：

Guo, Ruiting ^{[1
]}

Cui, Xixi ^{[1
]}

Li, Xue ^{[1
]}

Zang, Wen ^{[2
]}

Chang, Mingjie ^{[1
]}

Sun, Zenghui ^{[1
]}

Liu, Zhifang ^{[3
]}

Sun, Yundong ^{[1
]}

Jia, Jihui ^{[1
]}

Li, Wenjuan ^{[1
]}

机构：

[1] Shandong Univ, Shandong Prov Key Lab Infect & Immunol, Key Lab Expt Teratol,Chinese Minist Educ,Dept Pat, Sch Basic Med Sci,Shandong Univ Karolinska Inst C, Jinan, Peoples R China

[2] Rizhao Maternal & Child Hlth Care Hosp, Rizhao, Peoples R China

[3] Shandong Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Jinan, Peoples R China

来源：

CELL DEATH & DISEASE | 2022年 / 13卷 / 04期

基金：

中国国家自然科学基金;

关键词：

CIRCULAR RNA;

D O I：

10.1038/s41419-022-04811-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Helicobacter pylori (H. pylori) is one of the main causes of gastric cancer. It has been reported that circRNAs play a vital role in the development of multiple types of cancer. However, the role of H. pylori-induced circRNAs in the development of gastric cancer has not been studied. In this study, we found that H. pylori could induce the upregulation of circMAN1A2 in AGS and BGC823 cells independent of CagA. The downregulation of circMAN1A2 could inhibit the proliferation, migration and invasion of gastric cancer cells, and circMAN1A2 could promote the progression of gastric cancer induced by H. pylori by sponging miR-1236-3p to regulate MTA2 expression. Furthermore, circMAN1A2 knockdown inhibited xenograft tumour growth in vivo, and the overexpression of circMAN1A2 was associated with the progression of gastric cancer. Hence, Helicobacter pylori induced circMAN1A2 expression to promote the carcinogenesis of gastric cancer, and circMAN1A2 might be a new potential diagnostic marker and therapeutic target for gastric cancer.

引用

页数：11

共 38 条

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