Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: A review

被引：411

作者：

Elgadir, M. Abd ^{[1
]}

Uddin, Md. Salim ^{[2
]}

Ferdosh, Sahena ^{[3
]}

Adam, Aishah ^{[1
]}

Chowdhury, Ahmed Jalal Khan ^{[3
]}

Sarker, Md. Zaidul Islam ^{[2
]}

机构：

[1] Univ Teknol MARA, Fac Pharm, Dept Pharmacol & Chem, Bandar Puncak Alam 42300, Selangor, Malaysia

[2] Int Islamic Univ Malaysia, Fac Pharm, Dept Pharmaceut Technol, Kuantan 25200, Pahang, Malaysia

[3] Int Islamic Univ Malaysia, Fac Sci, Kuantan 25200, Pahang, Malaysia

来源：

JOURNAL OF FOOD AND DRUG ANALYSIS | 2015年 / 23卷 / 04期

关键词：

chitosan; drug delivery system; nanoparticle composite; wound healing; IN-VIVO EVALUATION; POORLY ABSORBABLE DRUGS; CONTROLLED-RELEASE; MOLECULAR-WEIGHT; INTESTINAL-ABSORPTION; CHITOSAN/CYCLODEXTRIN NANOPARTICLES; THIOLATED CHITOSANS; ANTITUMOR-ACTIVITY; OXIDIZED ALGINATE; VITRO;

D O I：

10.1016/j.jfda.2014.10.008

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Chitosan is a promising biopolymer for drug delivery systems. Because of its beneficial properties, chitosan is widely used in biomedical and pharmaceutical fields. In this review, we summarize the physicochemical and drug delivery properties of chitosan, selected studies on utilization of chitosan and chitosan-based nanoparticle composites in various drug delivery systems, and selected studies on the application of chitosan films in both drug delivery and wound healing. Chitosan is considered the most important polysaccharide for various drug delivery purposes because of its cationic character and primary amino groups, which are responsible for its many properties such as mucoadhesion, controlled drug release, transfection, in situ gelation, and efflux pump inhibitory properties and permeation enhancement. This review can enhance our understanding of drug delivery systems particularly in cases where chitosan drug-loaded nanoparticles are applied. Copyright (C) 2014, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.

引用

页码：619 / 629

页数：11

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