Comparison of the prevalence and associated factors of hyperactive delirium in advanced cancer patients between inpatient palliative care and palliative home care

被引：7

作者：

Hamano, Jun ^{[1
]}

Mori, Masanori ^{[2
]}

Ozawa, Taketoshi ^{[3
]}

Sasaki, Jun ^{[4
]}

Kawahara, Masanori ^{[5
]}

Nakamura, Asumi ^{[6
]}

Hashimoto, Kotaro ^{[7
]}

Hisajima, Kazuhiro ^{[8
]}

Koga, Tomoyuki ^{[9
]}

Goto, Keiji ^{[10
]}

Fukumoto, Kazuhiko ^{[11
]}

Morimoto, Yuri ^{[12
]}

Goshima, Masahiro ^{[13
]}

Sekimoto, Go ^{[14
]}

Baba, Mika ^{[15
]}

Oya, Kiyofumi ^{[16
]}

Matsunuma, Ryo ^{[17
]}

Azuma, Yukari ^{[18
]}

Imai, Kengo ^{[19
]}

Morita, Tatsuya ^{[19
,20
]}

Shinjo, Takuya ^{[21
]}

机构：

[1] Univ Tsukuba, Fac Med, Div Clin Med, 1-1-1 Tennoudai, Tsukuba, Ibaraki 3058575, Japan

[2] Seirei Mikatahara Gen Hosp, Shizuoka, Japan

[3] Megumi Zaitaku Clin, Yokohama, Kanagawa, Japan

[4] Yushoukai Med Corp, Tokyo, Japan

[5] Soshukai Okabe Clin Sendai, Sendai, Miyagi, Japan

[6] Himawari Clin, Chiba, Japan

[7] Fukushima Home Palliat Care Clin, Fukushima, Japan

[8] Dr GON Kamakura Clin, Kamakura, Kanagawa, Japan

[9] Nozominohana Clin, Chiba, Japan

[10] Himawari Clin, Kumamoto, Japan

[11] Iwata Home Care Clin, Shizuoka, Japan

[12] Morimoto Clin, Amagasaki, Hyogo, Japan

[13] Home Care Clin Kobe, Hyofo, Japan

[14] Sekimoto Clin, Kobe, Hyogo, Japan

[15] Suita Tokushukai Hosp, Dept Palliat Med, Suita, Osaka, Japan

[16] Aso Iizuka Hosp, Dept Palliat & Support Care, Fukuoka, Japan

[17] Kobe Univ, Dept Palliat Med, Grad Sch Med, Kobe, Hyogo, Japan

[18] Tokyo Metropolitan Canc & Infect Dis Ctr Komagome, Tokyo, Japan

[19] Seirei Mikatahara Gen Hosp, Seirei Hosp, Shizuoka, Japan

[20] Seirei Mikatahara Gen Hosp, Dept Palliat & Support Care, Palliat Care Team, Shizuoka, Japan

[21] Shinjo Clin, Kobe, Hyogo, Japan

来源：

CANCER MEDICINE | 2021年 / 10卷 / 03期

关键词：

advanced cancer patients; hyperactive delirium; inpatient palliative care; palliative home care; place of care; CHARLSON COMORBIDITY SCORE; SURVIVAL PREDICTION; MODIFIED PROGNOSIS; OUTCOMES; FREQUENCY; VALIDATION; AGITATION; SETTINGS; DISTRESS; IMPACT;

D O I：

10.1002/cam4.3661

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Hyperactive delirium is known to increase family distress and the burden on health care providers. We compared the prevalence and associated factors of agitated delirium in advanced cancer patients between inpatient palliative care and palliative home care on admission and at 3 days before death. Methods This was a post hoc exploratory analysis of two multicenter, prospective cohort studies of advanced cancer patients, which were performed at 23 palliative care units (PCUs) between Jan and Dec 2017, and on 45 palliative home care services between July and Dec 2017. Results In total, 2998 patients were enrolled and 2829 were analyzed in this study: 1883 patients in PCUs and 947 patients in palliative home care. The prevalence of agitated delirium between PCUs and palliative home care was 5.2% (95% CI: 4.2% - 6.3%) vs. 1.4% (0.7% - 2.3%) on admission (p < 0.001) and 7.6% (6.4% - 8.9%) vs. 5.4% (4.0% - 7.0%) 3 days before death (p < 0.001). However, multivariate logistic regression analysis revealed that the place of care was not significantly associated with the prevalence of agitated delirium at 3 days before death after adjusting for prognostic factors, physical risk factors, and symptoms. Conclusions There was no significant difference in the prevalence of agitated delirium at 3 days before death between inpatient palliative care and palliative home care after adjusting for the patient background, prognostic factors, symptoms, and treatment.

引用

页码：1166 / 1179

页数：14

共 32 条

[1] Delirium scales: A review of current evidence [J].

Adamis, Dimitrios ;

Sharma, Naveen ;

Whelan, Paul J. P. ;

Macdonald, Alastair J. D. .

AGING & MENTAL HEALTH, 2010, 14 (05) :543-555

[2] Survival prediction for advanced cancer patients in the real world: A comparison of the Palliative Prognostic Score, Delirium-Palliative Prognostic Score, Palliative Prognostic Index and modified Prognosis in Palliative Care Study predictor model [J].

Baba, Mika ;

Maeda, Isseki ;

Morita, Tatsuya ;

Inoue, Satoshi ;

Ikenaga, Masayuki ;

Matsumoto, Yoshihisa ;

Sekine, Ryuichi ;

Yamaguchi, Takashi ;

Hirohashi, Takeshi ;

Tajima, Tsukasa ;

Tatara, Ryohei ;

Watanabe, Hiroaki ;

Otani, Hiroyuki ;

Takigawa, Chizuko ;

Matsuda, Yoshinobu ;

Nagaoka, Hiroka ;

Mori, Masanori ;

Tei, Yo ;

Hiramoto, Shuji ;

Suga, Akihiko ;

Kinoshita, Hiroya .

EUROPEAN JOURNAL OF CANCER, 2015, 51 (12) :1618-1629

[3] Independent Validation of the Modified Prognosis Palliative Care Study Predictor Models in Three Palliative Care Settings [J].

Baba, Mika ;

Maeda, Isseki ;

Morita, Tatsuya ;

Hisanaga, Takayuki ;

Ishihara, Tatsuhiko ;

Iwashita, Tomoyuki ;

Kaneishi, Keisuke ;

Kawagoe, Shohei ;

Kuriyama, Toshiyuki ;

Maeda, Takashi ;

Mori, Ichiro ;

Nakajima, Nobuhisa ;

Nishi, Tomohiro ;

Sakurai, Hiroki ;

Shimoyama, Satofumi ;

Shinjo, Takuya ;

Shirayama, Hiroto ;

Yamada, Takeshi ;

Ono, Shigeki ;

Ozawa, Taketoshi ;

Yamamoto, Ryo ;

Tsuneto, Satoru .

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2015, 49 (05) :853-860

[4] The Memorial Delirium Assessment Scale [J].

Breitbart, W ;

Rosenfeld, B ;

Roth, A ;

Smith, MJ ;

Cohen, K ;

Passik, S .

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 1997, 13 (03) :128-137

[5] The delirium experience: Delirium recall and delirium-related distress in hospitalized patients with cancer, their spouses/caregivers, and their nurses [J].

Breitbart, W ;

Gibson, C ;

Tremblay, A .

PSYCHOSOMATICS, 2002, 43 (03) :183-194

[6] Impact of Delirium and Recall on the Level of Distress in Patients With Advanced Cancer and Their Family Caregivers [J].

Bruera, Eduardo ;

Bush, Shirley H. ;

Willey, Jie ;

Paraskevopoulos, Timotheos ;

Li, Zhijun ;

Palmer, J. Lynn ;

Cohen, Marlene Z. ;

Msn, Debra Sivesind ;

Elsayem, Ahmed .

CANCER, 2009, 115 (09) :2004-2012

[7] The frequency of missed delirium in patients referred to palliative care in a comprehensive cancer center [J].

de la Cruz, Maxine ;

Fan, Joanna ;

Yennu, Sriram ;

Tanco, Kimberson ;

Shin, SeongHoon ;

Wu, Jimin ;

Liu, Diane ;

Bruera, Eduardo .

SUPPORTIVE CARE IN CANCER, 2015, 23 (08) :2427-2433

[8] Delirium with severe symptom expression related to hypercalcemia in a patient with advanced cancer: an interdisciplinary approach to treatment [J].

Delgado-Guay, Marvin Omar ;

Yennurajalingam, Sriram ;

Bruera, Eduardo .

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2008, 36 (04) :442-449

[9]

Fainsinger R., 1991, Journal of Palliative Care, DOI DOI 10.1177/082585979100700102

[10]

Finch WH, 2010, J DATA SCI, V8, P361, DOI DOI 10.6339/JDS.2010.08(3).612

← 1 2 3 4 →