Artificial oxygen carriers as a possible alternative to red cells in clinical practice

被引：17

作者：

Barbosa, Fabiano Timbo ^{[1
]}

Juca, Mario Jorge ^{[1
]}

Castro, Aldemar Araujo ^{[1
]}

Duarte, Jose Lira ^{[1
]}

Barbosa, Luciano Timbo ^{[1
]}

机构：

[1] Dr Armando Lages Emergency Unit, Maceio, Alagoas, Brazil

来源：

SAO PAULO MEDICAL JOURNAL | 2009年 / 127卷 / 02期

关键词：

Hemoglobins; Anemia; Blood; Blood transfusion; Blood substitutes; BLOOD-TRANSFUSIONS; PERFLUBRON EMULSION; SURGICAL-PATIENTS; HEMOGLOBIN; SUBSTITUTES; SURGERY; PHYSIOLOGY; MORTALITY;

D O I：

10.1590/S1516-31802009000200008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fluid resuscitation is intended to eliminate microcirculatory disorders and restore adequate tissue oxygenation. The safety limits for a restrictive transfusion policy are given by patients' individual tolerance of acute normovolemic anemia. Artificial oxygen carriers based on perfluorocarbon or hemoglobin are attractive alternatives to allogenic red blood cells. There are many risks involved in allogenic blood transfusions and they include transmission of infections, delayed postoperative wound healing, transfusion reactions, immunomodulation and cancer recurrence. Regardless of whether artificial oxygen carriers are available for routine clinical use, further studies are needed in order to show the safety and efficacy of these substances for clinical practice.

引用

页码：97 / 100

页数：4

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