BLID: A Novel Tumor-Suppressor Gene

被引：3

作者：

Yu, Xin ^{[1
]}

Li, Zheng ^{[2
]}

机构：

[1] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Dermatol, Beijing 100021, Peoples R China

[2] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, Beijing 100021, Peoples R China

来源：

ONCOLOGY RESEARCH | 2015年 / 22卷 / 5-6期

基金：

中国国家自然科学基金;

关键词：

BH3-like motif containing; cell death inducer (BLID); Cancer; Tumor-suppressor gene (TSG); BREAST-CANCER; SIGNALING PATHWAY; DOWN-REGULATION; APOPTOSIS; FAMILY; RAS/RAF/MEK/ERK; SUSCEPTIBILITY; INHIBITORS; EXPRESSION; MUTATIONS;

D O I：

10.3727/096504015X14410238486568

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BLID (BH3-like motif containing, cell death inducer), also known as breast cancer cell 2 (BRCC2), was first reported in the human breast cancer cell line in 2004. BLID is a BH3-like motif containing apoptotic member of the Bcl-2 family. Recently, the BLID tumor-suppressor roles have been fully established. Several studies have found that BLID is frequently downregulated in many human cancers and the downregulation is often associated with tumor progression. Multivariate analysis indicated that BLID is an independent prognostic factor for overall survival and distant metastasis-free survival. Moreover, BLID can inhibit breast cancer cell growth and metastasis and promote apoptosis. BLID can regulate the expression of various tumor-related genes and proteins, such as AKT and MMP. In this review, we provide an overview of current knowledge concerning the role of BLID in tumor development and progression. To our knowledge, this is the first review about the role of this novel tumor-suppressor gene in tumor development and progression.

引用

页码：333 / 338

页数：6

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