Effect of DL-α-lipoic acid on the status of lipid peroxidation and antioxidants in aged rats

被引：53
作者：
Arivazhagan, P [1 ]
Juliet, P [1 ]
Panneerselvam, C [1 ]
机构：
[1] Univ Madras, Dept Med Biochem, DR ALM Post Grad Inst Basic Med Sci, Chennai 600113, Tamil Nadu, India
来源：
PHARMACOLOGICAL RESEARCH | 2000年 / 41卷 / 03期
关键词：
DL-alpha-lipoic acid; antioxidants; lipid peroxidation; ageing;
D O I：
10.1006/phrs.1999.0594
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of DL-alpha-lipoic acid on lipid peroxidation and antioxidants status has been studied in the blood of young and aged rats. Dr-alpha-lipoic acid, an antioxidant, was administered intraperitoneally for 7 and 14 days. Enzymatic and non-enzymatic antioxidant levels decreased with age but this decrease was attenuated by DL-alpha-lipoic acid. Lipid peroxide levels increased with age, and were decreased by lipoic acid administration. These results suggest that biochemical lesions which are considered to be part of the normal ageing process are neutralized by DL-alpha-lipoic acid. (C) 2000 Academic Press.
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页码：299 / 303
页数：5
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