Cytotoxic Bromine- and Iodine-Containing Cytochalasins Produced by the Mangrove Endophytic Fungus Phomopsis sp. QYM-13 Using the OSMAC Approach

被引：42

作者：

Chen, Yan ^{[1
,2
]}

Yang, Wencong ^{[1
]}

Zou, Ge ^{[1
]}

Wang, Guisheng ^{[2
]}

Kang, Wenyi ^{[2
]}

Yuan, Jie ^{[3
]}

She, Zhigang ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China

[2] Henan Univ, Natl R&D Ctr Edible Fungus Proc Technol, Kaifeng 475004, Peoples R China

[3] Sun Yat Sen Univ, Key Lab Trop Dis Control, Minist Educ, Guangzhou 510080, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2022年 / 85卷 / 05期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

MARINE;

D O I：

10.1021/acs.jnatprod.1c01115

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Twelve new cytochalasins, phomopchalasins D-O (1-3, 5-12, and 14), including one brominated (2) and two iodinated cytochalasins (3 and 6), together with six known analogues (4, 13, and 15-18) were isolated from the mangrovederived fungus Phomopsis sp. QYM-13 treated with 3% NaBr or 3% KI in potato liquid medium. Their structures and absolute configurations were established by extensive spectroscopic analysis (1D and 2D NMR, HRESIMS), electronic circular dichroism calculations, and a single-crystal X-ray diffraction experiment. Compounds 3 and 6 represent the first iodinated cytochalasins. Compounds 2, 15, 17, and 18 exhibited significant cytotoxicity against human cancer cell line MDA-MB-435 with IC50 values ranging from 0.2 to 8.2 mu M

引用

页码：1229 / 1238

页数：10

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