Histochemical characterization of skeletal muscles in rats with photochemically-induced stroke

被引：7

作者：

Abo, M ^{[1
]}

Miyano, S ^{[1
]}

Eun, SS ^{[1
]}

Yamauchi, H ^{[1
]}

机构：

[1] Jikei Med, Sch Med, Dept Rehabil Med, Minato Ku, Tokyo 1058461, Japan

来源：

BRAIN INJURY | 2004年 / 18卷 / 10期

关键词：

D O I：

10.1080/02699050410001672305

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Primary objective: The aim of this study was to assess skeletal muscle showing a complete functional recovery after induction of pan-necrotic lesions in the right sensorimotor cortex in rats. Research design and methods: A focal lesion of the right sensorimotor cortex was induced photochemically. Rats were divided into three groups; the sham-operated group ( CON), Stroke (RB) and Stroke plus severed right sciatic nerve (RBD). Main outcomes and results: All RB rats showed complete functional recovery in the beam-walking test within 10 days. The score of CON rats was 7 for 21 days. The wet weight of the soleus muscle ( SOL) only in the RB and RBD was significantly greater than in the CON. The cross-sectional area of type I fibres was increased in SOL. Conclusions: It was concluded that the functional recovery was mainly due to increased wet weight and cross-sectional area of type I SOL fibres, which probably reflected the functional reorganization and neuromodulation in the non-damaged contralateral sensorimotor cortex and ipsilateral sensorimotor cortex lateral to the lesion identified in a previous study.

引用

页码：1017 / 1024

页数：8

共 14 条

[1] Functional recovery after brain lesion - contralateral neuromodulation: an fMRI study [J].

Abo, M ;

Chen, ZG ;

Lai, LJ ;

Reese, T ;

Bjelke, B .

NEUROREPORT, 2001, 12 (07) :1543-1547

[2]

ABO M, 1999, J NEUROSCI, V25, pS322

[3]

ABO M, 2003, JAPANESE J REHABILIT, V40, P49

[4] Enzyme-histochemical and morphological characteristics of fast- and slow-twitch skeletal muscle after brain infarction in the rat [J].

Ansved, T ;

Ohlsson, AL ;

Jakobsson, F ;

Johansson, BB .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1996, 144 (1-2) :14-20

[5] HISTOGRAPHIC ANALYSIS OF HUMAN MUSCLE BIOPSIES WITH REGARD TO FIBER TYPES .2. DISEASES OF UPPER AND LOWER MOTOR NEURON [J].

BROOKE, MH ;

ENGEL, WK .

NEUROLOGY, 1969, 19 (04) :378-&

[6] HEMIPLEGIC AMYOTROPHY - MUSCLE AND MOTOR POINT BIOPSY STUDY [J].

CHOKROVERTY, S ;

REYES, MG ;

RUBINO, FA ;

BARRON, KD .

ARCHIVES OF NEUROLOGY, 1976, 33 (02) :104-110

[7] MUSCLE REARRANGEMENT IN PATIENTS WITH HEMIPARESIS AFTER STROKE - AN ELECTROPHYSIOLOGICAL AND MORPHOLOGICAL-STUDY [J].

DATTOLA, R ;

GIRLANDA, P ;

VITA, G ;

SANTORO, M ;

ROBERTO, ML ;

TOSCANO, A ;

VENUTO, C ;

BARADELLO, A ;

MESSINA, C .

EUROPEAN NEUROLOGY, 1993, 33 (02) :109-114

[8] MOTOR UNIT INVOLVEMENT IN SPASTIC PARESIS - RELATIONSHIP BETWEEN LEG MUSCLE ACTIVATION AND HISTOCHEMISTRY [J].

DIETZ, V ;

KETELSEN, UP ;

BERGER, W ;

QUINTERN, J .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1986, 75 (01) :89-103

[9]

EDSTROM L, 1970, Journal of the Neurological Sciences, V11, P537, DOI 10.1016/0022-510X(70)90104-8

[10] AMPHETAMINE, HALOPERIDOL, AND EXPERIENCE INTERACT TO AFFECT RATE OF RECOVERY AFTER MOTOR CORTEX INJURY [J].

FEENEY, DM ;

GONZALEZ, A ;

LAW, WA .

SCIENCE, 1982, 217 (4562) :855-857

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