Genes and Environment as Predisposing Factors in Autoimmunity: Acceleration of Spontaneous Thyroiditis by Dietary Iodide in NOD•H2h4 Mice

被引：21
|
作者：
Kolypetri, Panayota [1 ]
King, Justin [1 ]
Larijani, Mani [1 ]
Carayanniotis, George [1 ,2 ]
机构：
[1] Mem Univ Newfoundland, Div Biomed Sci, St John, NF A1B 3V6, Canada
[2] Mem Univ Newfoundland, Fac Med, Div Endocrinol, St John, NF A1B 3V6, Canada
来源：
INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2015年 / 34卷 / 06期
基金：
加拿大健康研究院;
关键词：
iodine; NOD center dot H2(h4) mice; thyroglobulin; thyroiditis; REGULATORY T-CELLS; NONOBESE DIABETIC MICE; DEFICIENT NOD.H-2H4 MICE; NOD MICE; IFN-GAMMA; DENDRITIC CELLS; B-CELLS; HASHIMOTOS-THYROIDITIS; ANTIGEN PRESENTATION; SJOGRENS-SYNDROME;
D O I：
10.3109/08830185.2015.1065828
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the field of autoimmune thyroiditis, NOD center dot H2(h4) mice have attracted significant and increasing attention since they not only develop spontaneous disease but they present thyroiditis with accelerated incidence and severity if they ingest iodide through their drinking water. This animal model highlights the interplay between genetic and dietary factors in the triggering of autoimmune disease and offers new opportunities to study immunoregulatory parameters influenced by both genes and environment. Here, we review experimental findings with this mouse model of thyroiditis.
引用
收藏
页码：542 / 556
页数：15
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