Intermittent Fasting Induces Hypothalamic Modifications Resulting in Low Feeding Efficiency, Low Body Mass and Overeating

被引:34
作者
Chausse, Bruno [1 ]
Solon, Carina [2 ]
Caldeira da Silva, Camille C. [1 ]
Masselli dos Reis, Ivan G. [3 ]
Manchado-Gobatto, Fulvia B. [3 ]
Gobatto, Claudio A. [3 ]
Velloso, Licio A. [2 ]
Kowaltowski, Alicia J. [1 ]
机构
[1] Univ Sao Paulo, Dept Bioquim, Inst Quim, BR-05508000 Sao Paulo, Brazil
[2] Univ Estadual Campinas, Fac Ciencias Med, BR-13083970 Campinas, SP, Brazil
[3] Univ Estadual Campinas, Fac Ciencias Aplicadas, BR-13084350 Campinas, Brazil
基金
巴西圣保罗研究基金会;
关键词
BROWN ADIPOSE-TISSUE; SELECTIVE LEPTIN RESISTANCE; CALORIC RESTRICTION; MITOCHONDRIAL PROTON; SKELETAL-MUSCLE; DIETARY RESTRICTION; UNCOUPLING PROTEIN-3; FOOD-INTAKE; FATTY-ACID; INSULIN;
D O I
10.1210/en.2013-2057
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Intermittent fasting (IF) is an often-used intervention to decrease body mass. In male Sprague-Dawley rats, 24 hour cycles of IF result in light caloric restriction, reduced body mass gain, and significant decreases in the efficiency of energy conversion. Here, we study the metabolic effects of IF in order to uncover mechanisms involved in this lower energy conversion efficiency. After 3 weeks, IF animals displayed overeating during fed periods and lower body mass, accompanied by alterations in energy-related tissue mass. The lower efficiency of energy use was not due to uncoupling of muscle mitochondria. Enhanced lipid oxidation was observed during fasting days, whereas fed days were accompanied by higher metabolic rates. Furthermore, an increased expression of orexigenic neurotransmitters AGRP and NPY in the hypothalamus of IF animals was found, even on feeding days, which could explain the overeating pattern. Together, these effects provide a mechanistic explanation for the lower efficiency of energy conversion observed. Overall, we find that IF promotes changes in hypothalamic function that explain differences in body mass and caloric intake.
引用
收藏
页码:2456 / 2466
页数:11
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