Vagus nerve stimulation...25 years later! What do we know about the effects on cognition?

被引：146

作者：

Vonck, Kristl ^{[1
]}

Raedt, Robrecht ^{[1
]}

Naulaerts, Joke ^{[1
]}

De Vogelaere, Frederick ^{[1
]}

Thiery, Evert ^{[1
]}

Van Roost, Dirk ^{[1
]}

Aldenkamp, Bert ^{[2
,3
]}

Miatton, Marijke ^{[1
]}

Boon, Paul ^{[1
,2
]}

机构：

[1] Ghent Univ Hosp, Dept Neurol, Lab Clin & Expt Neurophysiol Neurobiol & Neuropsy, B-9000 Ghent, Belgium

[2] Epilepsy Ctr Kempenhaeghe, NL-5590 AB Heeze, Netherlands

[3] Maastricht Univ, Med Ctr, NL-6200 MD Maastricht, Netherlands

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2014年 / 45卷

关键词：

Vagus nerve stimulation; Memory; Cognitive functioning; Quality of life; Norepinephrine; Alzheimer's disease; Epilepsy; Depression; Locus coeruleus; QUALITY-OF-LIFE; LOCUS-COERULEUS NEURONS; LONG-TERM POTENTIATION; ALZHEIMERS-DISEASE; DENTATE GYRUS; CENTRAL PROJECTIONS; GENE-EXPRESSION; AGED MICE; RAT; NOREPINEPHRINE;

D O I：

10.1016/j.neubiorev.2014.05.005

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

VNS therapy was delivered to patients for the first time in 1988. After 25 years, insight in the antiepileptic and antidepressant mechanism of action of VNS has grown steadily. The effects on cognition and especially memory remain controversial. This review provides an elaborate overview of studies addressing cognition and describes potential underlying mechanisms for the reported effects. Short-term VNS has an effect on verbal memory recognition when administered at the correct timing and dosage. Chronic VNS resulted into a positive effect on the cognitive status in an Alzheimer population. Positive effect of chronic VNS in epilepsy or depression patients on global cognitive functioning are less convincing. Neither do the results reveal a negative effect which has major implications for chronic treatment of neurology patients. A cascade of neurochemical processes put in motion by changes in NE concentrations in reaction to stimulation of the vagal nerve may underlie the VNS-induced effects on cognition and memory. In Alzheimer pathology, NE may act as an anti-inflammatory agent on brainstem nuclei. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：63 / 71

页数：9

共 76 条

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