Ammonificins A and B, Hydroxyethylamine Chroman Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans

被引：25

作者：

Andrianasolo, Eric H. ^{[1
]}

Haramaty, Liti ^{[1
]}

Rosario-Passapera, Richard ^{[1
]}

Bidle, Kelly ^{[2
]}

White, Eileen ^{[3
,4
,5
]}

Vetriani, Costantino ^{[1
]}

Falkowski, Paul ^{[1
]}

Lutz, Richard ^{[1
]}

机构：

[1] Rutgers State Univ, Inst Marine & Coastal Sci, Ctr Marine Biotechnol, New Brunswick, NJ 08901 USA

[2] Rider Univ, Dept Biol, Lawrenceville, NJ 08648 USA

[3] Rutgers State Univ, Dept Mol Biol & Biochem, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA

[4] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA

[5] Canc Inst New Jersey, New Brunswick, NJ 08903 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 06期

基金：

美国国家科学基金会;

关键词：

SP NOV; APOPTOSIS;

D O I：

10.1021/np800726d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two hydroxyethylamine chroman derivatives, ammonificins A (1) and B (2), were isolated from the marine hydrothermal vent bacterium Thermovibrio ammonificans. The molecular structures of these compounds were determined using a combination of NMR, mass spectrometry, and CD analyses. Biological activities were determined using an antimicrobial assay and the patented ApopScreen cell-based screen for apoptosis induction and potential anticancer activity. To our knowledge, this is the first report of secondary metabolites from the marine hydrothermal vent bacterium T ammonificans.

引用

页码：1216 / 1219

页数：4

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