Recent Advances in Enone and NO-Releasing Derivatives of Oleanolic Acid with Anti-cancer Activity

被引：4

作者：

Luo, Qun-Feng ^{[1
]}

Liu, Jin-Hong ^{[1
]}

Chen, Li ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Jiangsu, Peoples R China

来源：

MINI-REVIEWS IN ORGANIC CHEMISTRY | 2014年 / 11卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Anti-cancer; CDDO; enone derivative; nitric oxide (NO); NO-releasing derivative; oleanolic acid (OA); NITRIC-OXIDE PRODUCTION; LUNG-CANCER CELLS; ACTIVATED RECEPTOR-GAMMA; CDDO INDUCES APOPTOSIS; TUMOR-NECROSIS-FACTOR; SYNTHETIC TRITERPENOIDS; MOUSE MACROPHAGES; URSOLIC ACID; DOWN-REGULATION; LEUKEMIA-CELLS;

D O I：

10.2174/1570193X1103140915112325

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oleanolic acid (OA) is a natural pentacyclic triterpenoid acid with diverse biological activities including anti-inflammation, suppression of tumor promotion, protection of the liver against toxic injury, and induction of differentiation. However, the potency of OA as an anti-cancer agent is relatively weak. Therefore, remarkable progress has been made in the modification of OA to improve its anti-cancer activity over the past few years. This paper reviews the progress mainly on anti-cancer activity of enone derivatives and nitric oxide (NO)-releasing derivatives of OA over the last decade.

引用

页码：355 / 361

页数：7

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