Sulfuric acid promoted condensation cyclization of 2-(2-(trimethylsilyl) ethynyl)anilines with arylaldehydes in alcoholic solvents: an efficient one-pot synthesis of 4-alkoxy-2-arylquinolines

被引：32
作者：
Wang, Yong [1 ]
Peng, Changlan [1 ]
Liu, Lanying [1 ]
Zhao, Jiaji [1 ]
Su, Li [1 ]
Zhu, Qiang [1 ]
机构：
[1] Chinese Acad Sci, Inst Biol Chem, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 19期
关键词：
INDIRECT FRIEDLANDER SYNTHESIS; SUBSTITUTED QUINOLINES; 2,4-DISUBSTITUTED QUINOLINES; OXIDATIVE CYCLIZATION; RECENT PROGRESS; IN-VITRO; DERIVATIVES; 2-ARYL-1,2,3,4-TETRAHYDRO-4-QUINOLONES; 2-ARYLQUINOLINE; ANTIBACTERIAL;
D O I：
10.1016/j.tetlet.2009.02.206
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the synthesis of 4-alkoxy-2-arylquinolines has been developed. The reaction proceeds smoothly by heating a mixture of easily accessible 2-(2-(trimethylsilyl) ethynyl)anilines and arylaldehydes in alcoholic solvents in the presence of sulfuric acid. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2261 / 2265
页数：5
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