Lifetime cost-effectiveness of prophylactic implantation of a cardioverter defibrillator in patients with reduced left ventricular systolic function: results of Markov modelling in a European population

被引:64
作者
Cowie, Martin R. [1 ]
Marshall, Deborah [2 ,3 ]
Drummond, Michael [4 ]
Ferko, Nicole [5 ]
Maschio, Michael
Ekman, Matthias [6 ]
de Roy, Luc [7 ]
Heidbuchel, Hein [8 ]
Verboven, Yves
Braunschweig, Frieder [9 ]
Linde, Cecilia [9 ]
Boriani, Giuseppe [10 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England
[2] Univ Calgary, Fac Med, Dept Community Hlth Sci, Calgary, AB, Canada
[3] Principal Consultant i3 Innovus, Calgary, AB, Canada
[4] Univ York, Ctr Hlth Econ, York YO10 5DD, N Yorkshire, England
[5] i3 Innovus, Hlth Econ & Outcomes Res, Burlington, ON, Canada
[6] i3 Innovus, Hlth Econ & Outcomes Res, Stockholm, Sweden
[7] Clin Univ UCL Mont Godinne, Arrhythmol Unit, Yvoir, Belgium
[8] Univ Louvain, Univ Hosp Gasthuisberg, Clin EP Lab, Louvain, Belgium
[9] Karolinska Univ Hosp, Karolinska Inst, Dept Cardiol, Stockholm, Sweden
[10] Univ Bologna, S Orsola Malpighi Univ Hosp, Inst Cardiol, Bologna, Italy
来源
EUROPACE | 2009年 / 11卷 / 06期
关键词
Cost-effectiveness analysis; Decision analytic model; Europe; Prophylactic implantable cardioverter defibrillator; Sudden death; Left ventricular ejection fraction; SUDDEN CARDIAC DEATH; DILATED CARDIOMYOPATHY; PULSE-GENERATOR; TRIAL; PREVENTION; AMIODARONE; RISK; PACEMAKER; LONGEVITY; DISEASE;
D O I
10.1093/europace/eup068
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Current European guidelines recommend prophylactic implantation of cardioverter defibrillators (ICDs) in patients with a reduced left ventricular ejection fraction (LVEF) who are not in NYHA class IV and have reasonable life expectancy. Cost and benefit implications of this recommendation have not been reported from a European perspective. Markov modelling estimated lifetime costs and effects [life years (LY) and quality-adjusted LY (QALY) gained] of prophylactic ICD implantation vs. conventional treatment, among patients with a reduced LVEF. Efficacy was estimated from a meta-analysis of mortality rates in the six primary prevention trials with inclusion criteria matching ACC/AHA/ESC Class I or IIa recommendations. Direct medical costs were estimated using Belgian national references. Costs and effects were discounted at 3 and 1.5% per annum, respectively. Probabilistic sensitivity and scenario analyses estimated the uncertainty around the incremental cost-effectiveness ratio. An ICD implantation increased the lifetime direct costs by Euro46 413. Estimated mean LY/QALY gained were 1.88/1.57, respectively. Probabilistic analysis estimated mean lifetime cost per QALY gained as Euro31 717 (95% CI: Euro19 760-Euro61 316). Cost-effectiveness was influenced most by ICD efficacy, time to replacement, utility, and patient age at implantation. In a European healthcare setting, prophylactic ICD implantation may be cost-effective if current guidelines for patients with a reduced LVEF are followed.
引用
收藏
页码:716 / 726
页数:11
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