Correlation between oxidative stress and immunosuppressive therapy in renal transplant recipients with an uneventful postoperative course and stable renal function

被引:43
作者
Perrea, Despina N.
Moulakakis, Konstantinos G. [1 ]
Poulakou, Maria V.
Vlachos, Ioannis S.
Papachristodoulou, Antonios
Kostakis, Alkiviadis I.
机构
[1] Univ Athens, Laiko Hosp, Sch Med, Dept Propedeut Surg 2, Athens, Greece
[2] Univ Athens, Sch Med, Lab Expt Surg & Surg Res, Athens, Greece
关键词
renal transplantation; oxidative stress; MDA; immunosuppressive; Tacrolimus; cyclosporine; reactive oxygen species;
D O I
10.1007/s11255-006-0054-x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background Reactive oxygen species (ROS) are important mediators of cellular damage and lipid peroxidation is the most important expression of ROS-induced oxidative stress. Recent studies have suggested that increased plasma malondialdehyde (MDA) levels are a consequence of specific immunosuppressive therapies. This study aims at investigating the relation between oxidative stress and immunosuppressive therapies in renal transplant patients with stable renal function and uneventful postoperative course. Methods The study group included 26 renal patients. Two groups of renal transplant recipients, treated with a different combination of immunosuppressive agents were studied (Group A: CyA, MMF, Steroids and Basiliximab, Group B: Tacrolimus, MMF, Steroids and Daclizumab). All patients had an uneventful postoperative course. Plasma MDA levels were measured before transplantation, 1 and 6 months after. Plasma concentration of endogenous creatinine (Cr) was used as a measure of stable renal function. Results Levels of MDA were increased before the transplantation in all renal patients (MDA: 7.81 +/- 4.81, normal levels: 2.23-1.08 nmol/ml, P < 0.05). Combined therapy with CYA was associated with high values of MDA at 6 months measurement after transplantation. However this tendency of increased MDA levels did not achieve a statistical significance (Group A: 6.97 vs. 9.06 nmol/ml, P > 0.05). On the contrary, statistically significant diminution of MDA levels was observed in Group B patients (Tacrolimus-MMF-steroids) at 6 months measurement after transplantation. (Group B: 8.61 vs. 4.11 nmol/ml, P < 0.02 < 0.05). Conclusions Immunosuppressive combined therapy with CyA was associated with the high values of MDA that were measured posttransplantly. Our study provides strong evidence that Tacrolimus is significantly associated with improved free radical metabolism.
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页码:343 / 348
页数:6
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