Synthesis, Characterization and Antitumor Activities of Platinum(II) Complexes

被引：1
|
作者：
Wang, Qingkun [1 ]
Pu, Shaoping [1 ]
Li, Yongnian [1 ]
He, Jian [1 ]
Jin, Jie [1 ]
Zhang, Qi [1 ]
机构：
[1] Kunming Gui Yan Pharmaceut Co Ltd, Kunming 650106, Peoples R China
来源：
FRONTIERS OF CHEMICAL ENGINEERING, METALLURGICAL ENGINEERING AND MATERIALS II | 2013年 / 803卷
关键词：
platinum complex; synthesis; characterization; antitumor activity; COMBINATION; DERIVATIVES; CISPLATIN; MODELS;
D O I：
10.4028/www.scientific.net/AMR.803.145
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
In order to obtain the mixed isobutylamine /cyclopentylamine platinum complexes with chloride and oxalic acid ions as leaving groups. The title compounds were synthetised from potassiumtetrachloroplatinate(II) by the reaction with potassium iodide, cyclopentylamine, isobutylamine, silver nitrate, potassium chloride, potassium oxalate monohydrate. The complexes structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR and the anticancer activity were measured by MTT method. The results showed that its structure was consistent with the title compound and had inhibiting effect on the growth of tumor cell lines in vitro.
引用
收藏
页码：145 / 148
页数：4
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