Facile method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by SiO2-H3PW12O40 in water

被引：23

作者：

Alinezhad, Heshmatollah ^{[1
]}

Soleymani, Elham ^{[1
]}

Zare, Mahboobeh ^{[2
]}

机构：

[1] Univ Mazandaran, Dept Organ Chem, Fac Chem, Babol Sar, Iran

[2] Amol Univ Special Modern Technol, Fac Sci & Herbs, Amol, Iran

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2017年 / 43卷 / 01期

关键词：

2,3-Dihydroquinazolin-4(1H)-one; SiO2-H3PW12O40; 2-Aminobenzamide; Heterogeneous catalyst; REUSABLE HETEROGENEOUS CATALYST; HIGHLY EFFICIENT SYNTHESIS; HETEROPOLY ACID; GREEN SYNTHESIS; IONIC LIQUID; DERIVATIVES; NITRATE; MILD;

D O I：

10.1007/s11164-016-2634-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 12-tungstophosphoric acid supported on silica gel (PW/SiO2) exhibits excellent activity in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones by cyclocondensation reaction of 2-aminobenzamide with carbonyl compounds in water under reflux conditions. The desired products have been obtained in short reaction times in high yields. Our method has been successfully applied for both aldehydes and ketones (aromatic and aliphatic). Easy recovery and reusable catalyst, easy work-up and avoidance of using harmful organic solvents are the major advantages of our method in comparison to existing methods.

引用

页码：457 / 466

页数：10

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