Coagulopathy of Acute Liver Failure

被引：81
作者：
Munoz, Santiago J. [1 ,2 ]
Stravitz, R. Todd [3 ]
Gabriel, Don A. [4 ]
机构：
[1] PENN Presbyterian Med Ctr, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Philadelphia, PA 19104 USA
[3] Virginia Commonwealth Univ, Sect Hepatol, Hume Lee Transplant Ctr, Richmond, VA 23298 USA
[4] Univ N Carolina, Sch Med, Div Hematol Oncol, Chapel Hill, NC 27599 USA
来源：
CLINICS IN LIVER DISEASE | 2009年 / 13卷 / 01期
关键词：
Coagulopathy; Liver; Hepatitis; Fulminant; Plasma; Factor VII; Clotting; FULMINANT HEPATIC-FAILURE; FRESH-FROZEN PLASMA; DISSEMINATED INTRAVASCULAR COAGULATION; RECOMBINANT FACTOR VIIA; GASTROINTESTINAL HEMORRHAGE; PORTAL-HYPERTENSION; PLATELET-FUNCTION; PROTHROMBIN TIME; ANTITHROMBIN-III; EARLY INDICATORS;
D O I：
10.1016/j.cld.2008.10.001
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Coagulopathy is an essential component of the acute liver failure (ALF) syndrome and reflects the central role of liver function in hemostasis. ALF is a syndrome characterized by the development of hepatic encephalopathy and coagulopathy within 24 weeks of the onset of acute liver disease. Coagulopathy in this setting is a useful prognostic tool in ALF and a dynamic indicator of the hepatic function. If severe, it can be associated with bleeding and is commonly a major obstacle to the performance of invasive procedures in patients with ALF. This review focuses on the epidemiology, pathophysiology, presentation, evaluation, and management of coagulopathy in ALF.
引用
收藏
页码：95 / +
页数：14
相关论文
共 77 条
  • [41] MOR E, 1993, SURG GYNECOL OBSTET, V176, P219
  • [42] The coagulopathy of acute liver failure and implications for intracranial pressure monitoring
    Munoz, Santiago J.
    Reddy, K. Rajender
    Lee, William
    [J]. NEUROCRITICAL CARE, 2008, 9 (01) : 103 - 107
  • [43] MUNOZ SJ, 1991, GASTROENTEROLOGY, V100, P1480
  • [44] MUNOZ SJ, 1993, SEMIN LIVER DIS, V13, P395
  • [45] MUNOZ SJ, 1989, TRANSPLANT P, V21, P3535
  • [46] OGRADY JG, 1988, Q J MED, V69, P817
  • [47] COAGULOPATHY OF FULMINANT HEPATIC-FAILURE
    OGRADY, JG
    LANGLEY, PG
    ISOLA, LM
    ALEDORT, LM
    WILLIAMS, R
    [J]. SEMINARS IN LIVER DISEASE, 1986, 6 (02) : 159 - 163
  • [48] EARLY INDICATORS OF PROGNOSIS IN FULMINANT HEPATIC-FAILURE
    OGRADY, JG
    ALEXANDER, GJM
    HAYLLAR, KM
    WILLIAMS, R
    [J]. GASTROENTEROLOGY, 1989, 97 (02) : 439 - 445
  • [49] OKUMOTO K, 2007, J GASTROEN HEPATOL, V8, P1171
  • [50] ORDINAS A, 1993, GASTROENTEROLOGY, V105, P148
12345678