Coagulopathy of Acute Liver Failure

被引：81
作者：
Munoz, Santiago J. [1 ,2 ]
Stravitz, R. Todd [3 ]
Gabriel, Don A. [4 ]
机构：
[1] PENN Presbyterian Med Ctr, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Philadelphia, PA 19104 USA
[3] Virginia Commonwealth Univ, Sect Hepatol, Hume Lee Transplant Ctr, Richmond, VA 23298 USA
[4] Univ N Carolina, Sch Med, Div Hematol Oncol, Chapel Hill, NC 27599 USA
来源：
CLINICS IN LIVER DISEASE | 2009年 / 13卷 / 01期
关键词：
Coagulopathy; Liver; Hepatitis; Fulminant; Plasma; Factor VII; Clotting; FULMINANT HEPATIC-FAILURE; FRESH-FROZEN PLASMA; DISSEMINATED INTRAVASCULAR COAGULATION; RECOMBINANT FACTOR VIIA; GASTROINTESTINAL HEMORRHAGE; PORTAL-HYPERTENSION; PLATELET-FUNCTION; PROTHROMBIN TIME; ANTITHROMBIN-III; EARLY INDICATORS;
D O I：
10.1016/j.cld.2008.10.001
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Coagulopathy is an essential component of the acute liver failure (ALF) syndrome and reflects the central role of liver function in hemostasis. ALF is a syndrome characterized by the development of hepatic encephalopathy and coagulopathy within 24 weeks of the onset of acute liver disease. Coagulopathy in this setting is a useful prognostic tool in ALF and a dynamic indicator of the hepatic function. If severe, it can be associated with bleeding and is commonly a major obstacle to the performance of invasive procedures in patients with ALF. This review focuses on the epidemiology, pathophysiology, presentation, evaluation, and management of coagulopathy in ALF.
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收藏
页码：95 / +
页数：14
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