Absence of the human CYP2C8*3 allele in Ugandan children exposed to Plasmodium falciparum malaria

被引：3

作者：

Paganotti, Giacomo Maria ^{[1
,2
]}

Cosentino, Valentina ^{[2
]}

Russo, Gianluca ^{[2
]}

Tabacchi, Francesca ^{[2
]}

Gramolelli, Silvia ^{[3
]}

Coluzzi, Mario ^{[2
]}

Romano, Rita ^{[2
]}

机构：

[1] Univ Botswana, Univ Penn, Gaborone, Botswana

[2] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy

[3] Hannover Med Sch, Inst Virol, Hannover, Germany

来源：

INFECTION GENETICS AND EVOLUTION | 2014年 / 27卷

关键词：

Plasmodium falciparum malaria; CYP2C8; Pharmacogenetics; Uganda; pfmdr1; Malaria drug resistance; GENETIC POLYMORPHISMS; CYP2C8; POLYMORPHISMS; PREVALENCE; METABOLISM; PFMDR1; PACLITAXEL;

D O I：

10.1016/j.meegid.2014.08.011

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Study of host pharmacogenetics can improve our knowledge of mechanisms of drug resistance selection and spread. This issue has recently been addressed with respect to chloroquine and amodiaquine in malaria endemic areas of West and East Africa. Here we report, from surveys performed in two different areas of Uganda, that the human CYP2C8*3 allele, which had been reported to be strongly associated with parasite drug resistance in Zanzibar, is absent, being a marker of genetic admixture of the Zanzibari population with a Caucasoid component. Moreover, a retrospective analysis of CYP2C8*2 and the Plasmodium falciparum drug resistant pfmdr1 86Y allele does not show any association, which may be related to the high level of drug resistance. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：432 / 435

页数：4

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