Liposome Loaded Chitosan Hydrogels, a Promising Way to Reduce the Burst Effect in Drug Release A comparativ analysis

被引：0

作者：

Paun, Vladimir Alexandru ^{[1
]}

Popa, Marcel ^{[2
]}

Desbrieres, Jacques ^{[3
]}

Peptu, Catalina Anisoara ^{[2
]}

Dragan, Stelian Valentin ^{[4
]}

Zegan, Georgeta ^{[5
]}

Cioca, Gabriela ^{[6
]}

机构：

[1] ENSTA ParisTech, Comp Sci & Syst Engn Dept, Palaiseau, France

[2] Gheorghe Asachi Tech Univ Iasi, Dept Nat & Synthet Polymers, 73 D Mangeron Blvd, Iasi 700050, Romania

[3] Univ Pau & Pays Adour, IPREM UMR CNRS 5254, Helioparc Pau Pyrenees,2 Ave P Angot, F-64503 Pau 9, France

[4] Alexandru Ioan Cuza Univ, Fac Phys, 11 Carol 1 Blvd, Iasi 700506, Romania

[5] Grigore T Popa Univ Med & Pharm, Fac Med Dent, Dept Surg, 4 Agatha Barsescu Str, Iasi 700074, Romania

[6] Lucian Blaga Univ Sibiu, Fac Med, 10 Victoriei Blvd, Sibiu 550024, Romania

来源：

MATERIALE PLASTICE | 2016年 / 53卷 / 04期

关键词：

liposome; chitosan; drug release; Fickian diffusion; EPSILON((INFINITY)) SPACE-TIME; SCALE RELATIVITY THEORY; HYDRODYNAMIC MODEL; POLYMER; MECHANISM;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In order to analyze the effect induced by encapsulating the drug in liposomes, comparative studies were performed for control hydrogels and complex systems (the same hydrogels containing liposomes). The results showed that the use of liposomes entrapped within chitosan hydrogels allows a strong decrease of burst effect and, moreover, the mechanism of drug release is a complex Fickian diffusion, consisting of drug diffusion through the swollen hydrogel and/or water filled pores, being continuously fed by calcein loaded in liposomes.

引用

页码：590 / 593

页数：4