Structure-activity relationships of non-imidazole H3 receptor ligands.: Part 1

被引：25

作者：

Faghih, R ^{[1
]}

Dwight, W ^{[1
]}

Gentles, R ^{[1
]}

Phelan, K ^{[1
]}

Esbenshade, TA ^{[1
]}

Ireland, L ^{[1
]}

Miller, TR ^{[1
]}

Kang, CH ^{[1
]}

Fox, GB ^{[1
]}

Gopalakrishnan, SM ^{[1
]}

Hancock, AA ^{[1
]}

Bennani, YL ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut Res & Dev, Neurosci Res, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(02)00309-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

SAR studies for novel non-imidazole containing H-3 receptor antagonists with high potency and selectivity for rat H-3 receptors are described. A high throughput screening lead, A-923, was further elaborated in a systematic manner to clarify a pharmacophore for this class of aryloxyalkyl piperazine based compounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2031 / 2034

页数：4

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