Selective activation of the sympathetic ganglia by centrally administered corticotropin-releasing factor in rats

被引：11
作者：
Usui, Daisuke [1 ,2 ]
Yamaguchi-Shima, Naoko [1 ]
Okada, Shoshiro [1 ]
Shimizu, Takahiro [1 ]
Wakiguchi, Hiroshi [2 ]
Yokotani, Kunihiko [1 ]
机构：
[1] Kochi Univ, Sch Med, Dept Pharmacol, Nanko Ku, Kochi 7838505, Japan
[2] Kochi Univ, Sch Med, Dept Pediat, Nanko Ku, Kochi 7838505, Japan
来源：
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2009年 / 146卷 / 1-2期
关键词：
Corticotropin-releasing factor; Sympatho-adrenomedullary system; Sympathetic ganglion; c-Fos; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ADRENAL EPINEPHRINE SECRETION; AUTONOMIC NERVOUS-SYSTEM; SPINAL-CORD; PREGANGLIONIC NEURONS; GENE-EXPRESSION; RECEPTOR; HORMONE; OUTFLOW; BRAIN;
D O I：
10.1016/j.autneu.2008.12.008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The sympathetic efferent pathway projects to the sympathetic ganglia and the adrenal medulla. In this study, we examined centrally administered corticotropin-releasing factor (CRF)-induced neuronal activation of noradrenergic postganglionic neurons in several kinds of the sympathetic ganglia (superior cervical, stellate and celiac ganglia) in anesthetized rats. CRF significantly increased c-Fos expression in the celiac and stellate ganglia, with more pronounced effect on the celiac ganglion. On the other hand, CRF had no effect on c-Fos expression in the superior cervical ganglion even at a higher dose. These results suggest that brain CRF selectively regulates neuronal activity of each sympathetic ganglion. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：111 / 114
页数：4
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