Synthesis of the C1-C27 portion of the aplyronines

被引：9

作者：

Calter, MA ^{[1
]}

Zhou, JG ^{[1
]}

机构：

[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 25期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tetlet.2004.04.159

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This manuscript describes the use of the anti,anti-diastereoselective aldol reaction of an efficiently generated dipropionate equivalent to construct the C-5-C-14-portion of the aplyronines. This portion was then coupled with a compound corresponding to C-15-G(20) of the targets. Further elaboration and an additional coupling led to an intermediate containing C-1-C-27 with appropriate stereochemistry and functionalization for eventual conversion into the aplyronines. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：4847 / 4850

页数：4

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