Cytotoxic tigliane-type diterpenoids from Croton tiglium

被引：29
|
作者：
Zhang, Dong-Dong [1 ]
Zhou, Bin [1 ]
Yu, Jin-Hai [1 ]
Xu, Cheng-Hui [1 ]
Ding, Jian [1 ]
Zhang, Hua [1 ]
Yue, Jian-Min [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
来源：
TETRAHEDRON | 2015年 / 71卷 / 52期
关键词：
Croton tiglium; Diterpenoid; Tigliane; Cytotoxicity; PHORBOL ESTERS; CLERODANE DITERPENOIDS; PROTEIN-KINASE; TONKINENSIS; AGENTS; EUPHORBIACEAE; CONSTITUENTS; INHIBITORS; LEAVES; ASSAY;
D O I：
10.1016/j.tet.2015.10.070
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chemical study on the twigs and leaves of Croton tiglium has led to the isolation of 11 new tigliane-type diterpenoids, crotignoids A-K(1-11), along with eight known analogues (12-19). The structures of these compounds were elucidated on the basis of detailed spectroscopic analysis. In vitro cytotoxic assays revealed moderate inhibition of compounds 1-10 toward human HL-60 and A549 tumor cells, with 1 exhibiting the strongest activity against HL-60 cell line with an IC50 value of 1.61 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9638 / 9644
页数：7
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